The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie +20 more
wiley +1 more source
Proactive consultation-liaison-services (CL): comparing PHQ-4 screening with traditional referral pathways in medical inpatients - a prospective comparative pilot study. [PDF]
Köbler P +5 more
europepmc +1 more source
A minimally invasive optical window enables stable, long‐term imaging of peripheral nerves in vivo at single‐axon resolution. Dynamic processes of degeneration, regeneration, and cellular remodeling are visualized across multiple time scales within the same nerve region, providing a unique platform to study a variety of anatomical and molecular events ...
Igor D. Luzhansky +15 more
wiley +1 more source
Implementation of Mobile-Based Programs for Alcohol Cessation in the Treatment of Alcohol-associated Liver Disease: Protocol for a Type 1 Hybrid Implementation-Effectiveness Trial. [PDF]
He C +9 more
europepmc +1 more source
A straightforward method is introduced to produce ion‐gel films with very low surface roughness by employing a solution‐shearing coating process. These ion‐gel films permit the growth of crystalline thin films of various small molecule organic semiconductor molecules directly on top of the ion‐gel layer, thereby enabling “inverted” small molecule ...
Jonathan Perez Andrade +10 more
wiley +1 more source
Ergonomic Sponge Electrodes From Recycled PEDOT:PSS
ABSTRACT Emerging technologies in human–machine interfacing increasingly aim to develop solutions that naturally conform to the body's unique characteristics. Ergonomics and electrical performance in cutaneous sensing are crucial for accurate and reliable translation of biosignals.
Matías Ceballos +3 more
wiley +1 more source
A vision for an academic health science centre: A survey of research engagement and barriers. [PDF]
Hughes G +11 more
europepmc +1 more source
Cavity Microelectrode Arrays for Electrical Recordings From Neurons
Microelectrode arrays (MEAs) are used to study electrophysiological activity. However, their signals are small with high noise. By adding a 100‐nanometer‐high cavity above the electrode, which reduces impedance without affecting resolution, we improve signal quality.
Johannes Lewen +2 more
wiley +1 more source
The diagnostic accuracy of AI-assisted diabetic retinopathy screening in primary care: a prospective validation study. [PDF]
Krogh M +7 more
europepmc +1 more source

