Results 171 to 180 of about 14,746 (313)

North Pontic crossroads: Mobility in Ukraine from the Bronze Age to the early modern period [PDF]

Sci Adv
Saag L, Utevska O, Zadnikov S, Shramko I, Gorbenko K, Bandrivskyi M, Pavliv D, Bruyako I, Grechko D, Okatenko V, Toshev G, Andrukh S, Radziyevska V, Buynov Y, Kotenko V, Smyrnov O, Petrauskas O, Magomedov B, Didenko S, Heiko A, Reida R, Sapiehin S, Aksonov V, Laptiev O, Terskyi S, Skorokhod V, Zhyhola V, Sytyi Y, Järve M, Scheib CL, Anastasiadou K, Kelly M, Williams M, Silva M, Barrington C, Gilardet A, Macleod R, Skoglund P, Thomas MG.   +38 more
europepmc   +2 more sources

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Genetic continuity of Indo-Iranian speakers since the Iron Age in southern Central Asia. [PDF]

Sci Rep, 2022
Guarino-Vignon P, Marchi N, Bendezu-Sarmiento J, Heyer E, Bon C.   +4 more
europepmc   +1 more source

Engineering Oncolytic Virus‐Armed Macrophages for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
ZIFOA‐M is engineered by conjugating oncolytic adenovirus‐loaded ZIF‐8 nanoparticles onto macrophage surfaces via bioorthogonal chemistry. Upon tumor infiltration, the platform releases OA to downregulate CD47/CD24 on tumor cells, restoring macrophage phagocytosis.
Jilong Wang, Ning Lu, Zhuo Yan, Luyi Ye, Luyao Bai, Shanshan Yuan, Yuting Zhu, Yiru Xiong, Yongheng Bai, Yaping Chen, Junjie Deng   +10 more
wiley   +1 more source

Scalable Engineering of Bio‐Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient‐Derived Models

Advanced Science, EarlyView.
Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole, Andrew Lai, Alexander Quinn, Marianne Gillard, Dominic Guanzon, Katherin Scholz‐Romero, Alexis Salas‐Burgos, Bastián Lillo Dapremont, Rohan Lourie, Naven Chetty, Richard Lobb, Kate Beecher, Amy E. McCart Reed, Kaltin Ferguson, Biao Sun, Yaowu He, John D. Hooper, Carlos Salomon   +17 more
wiley   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Re-evaluating Scythian lifeways: Isotopic analysis of diet and mobility in Iron Age Ukraine. [PDF]

PLoS One, 2021
Ventresca Miller AR, Johnson J, Makhortykh S, Gerling C, Litvinova L, Andrukh S, Toschev G, Zech J, le Roux P, Makarewicz C, Boivin N, Roberts P.   +11 more
europepmc   +1 more source

Review of Alan J. K. Sanders, 'Historical Dictionary of Mongolia' [PDF]

, 2005
Lane, George
core   +1 more source

Quantum Dots for Biomedical Biosensing, NIR‐II Bioimaging, and Phototherapy: Materials Design, Signal Transduction, and Translational Barriers

Advanced Science, EarlyView.
This review outlines bottom‐up and biomimetic fabrication strategies of quantum dots, and highlights their emerging applications in biosensing, multimodal bioimaging, and intelligent cancer theranostics. It further discusses key translational barriers and future perspectives for advancing QD‐based nanomedicine toward clinical implementation.
Jie Ju, Zhifang Liu, Xinran Gao, Wen Sun, Wei Fu, Yanfei Wang   +5 more
wiley   +1 more source

Mongolia-Central Asia relations and the implications of the rise of China on its future evolution. [PDF]

Int Polit (Hague), 2023
Irgengioro J.
europepmc   +1 more source