Results 231 to 240 of about 127,181,101 (300)

Transcription Factor HOXC11 Drives Colorectal Cancer Progression and Metastasis via CAMK2A‐Dependent CXCL5 Upregulation

Advanced Science, EarlyView.
HOXC11 drives colorectal cancer progression by transcriptionally activating CAMK2A, which triggers NF‐κB–dependent CXCL5 upregulation. CXCL5–CXCR2 signaling further reinforces HOXC11 expression through the ERK1/2–SP1 axis, forming a prometastatic positive feedback loop that is effectively disrupted by combined CAMK2A and CXCR2 inhibition.
Qingyang Sun, Hengjie Xu, Sheng Yang, Jiahui Zhou, Chuanxin Tian, Hongxu Nie, Chi Jin, Tuo Wang, Zhihao Chen, Junwei Tang, Yifei Feng, Xiaowei Wang, Yueming Sun   +12 more
wiley   +1 more source

Sonoselective Transfection of Glioma Endothelium

Advanced Science, EarlyView.
Delivering non‐viral, gene‐bearing nanoparticles with thiol‐decorated surfaces to gliomas with focused ultrasound yields transfection tropism for endothelial cells. From this platform, “sonoselective” transfection of glioma endothelium is achieved via incorporation of an endothelial cell‐specific promoter.
Anna C. Debski, Catherine M. Gorick, Victoria R. Breza, Jackson Tirrell, Krishan Perumal, Katherine M. Nowak, Ji Song, Natasha D. Sheybani, Richard J. Price   +8 more
wiley   +1 more source

Commodity risk assessment of <i>Hamamelis mollis</i> plants from the UK. [PDF]

EFSA J
EFSA Panel on Plant Health (PLH), Civera AV, Baptista P, Berlin A, Chatzivassiliou E, Cubero J, Cunniffe N, de la Peña E, Desneux N, Di Serio F, Filipiak A, Gonthier P, Hasiów-Jaroszewska B, Jactel H, Landa BB, Maistrello L, Makowski D, Milonas P, Papadopoulos NT, Susi H, van der Gaag DJ, Debode J, Navas-Cortes JA, Kritikos C, Kormpi M, Papachristos D, Reppa C, Akrivou A, Antonatos S, Beris D, Schulz OM, Lombardo MF, Gardi C, Potting R.   +33 more
europepmc   +1 more source

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

A critical moment for neonatology: appeals from the Lancet Child & Adolescent Health Commission. [PDF]

Ital J Pediatr
Dani C, Corsello G, De Luca D, Agosti M.
europepmc   +1 more source

Regulatory Whack-a-mole: A Rapid Scoping Review of Gambling Marketing Restrictions and their (in)Effectiveness. [PDF]

Curr Addict Rep
Torrance J, Smith J, Russell AMT, Wright S, Xiao LY, Wyn-Davies E, Heath C, Newall P.   +7 more
europepmc   +1 more source

On the Birth of US Family Medicine and the Residency Assistance Program. [PDF]

Fam Med
Gilchrist VJ, Graham R, Kahn NB, Ostergaard DJ, Heide K.   +4 more
europepmc   +1 more source

Surgery 4.0: From the Smart Operating Room to the Learning Operating Room. [PDF]

J Clin Med
Gumbs AA, Croner R, Couffinhal JC.
europepmc   +1 more source

Rbp-Jκ controls NK cell late maturation and migration via chromatin landscape remodeling. [PDF]

Proc Natl Acad Sci U S A
Peng H, Yang Y, Liu Y, Wu S, Hu D, Deng X, Huang L, Li Y, Xiong P, Yang Q, Li S, Gong B, Zhang Y, Song L, Wang F, Yu J, Xiao Z, Deng Y, Zhong Z, Deng Y.   +19 more
europepmc   +1 more source

The Missing Block: Regional Anaesthesia as the Unseen Driver of Post-Thoracoscopic Pain Trajectories. [PDF]

Eur J Pain
Zhang Z, Fan R.
europepmc   +1 more source