Results 131 to 140 of about 126,944,329 (258)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Transporte de fônons em geometrias fractais [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Elétrica, Florianópolis, 2010O transporte térmico em geometrias fractais é investigado utilizando o formalismo de funções de ...
Rocha, Edroaldo Lummertz da
core  

Green's Function for Discrete Second-Order Problems with Nonlocal Boundary Conditions

Boundary Value Problems, 2011
We investigate a second-order discrete problem with two additional conditions which are described by a pair of linearly independent linear functionals.
Roman Svetlana, Štikonas Artūras   +1 more
doaj  

Nonuniqueness of the Green’s Function for Neumann’s Boundary-Value Problems

Axioms
Green’s functions for linear two-point boundary-value problems subject to non-homogeneous Neumann’s boundary conditions are derived. It is shown that, for the differential operator L(y)=y″+ky with k≠nπ/L where n is a natural number or zero, the Green ...
Juan I. Ramos, Carmen M. García-López
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The Discrete Error Analysis of GREEN’s Function Sampled in Real Space

, 2011
During the near-field acoustic holographic reconstruction, there will be error which make the reconstruction uncertain in sampling GREEN’s function in real space.
Xu Yu, Tang Bo
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Numerical integration methods for fast evaluation of the acoustic quasi-periodic Green’s function [PDF]

The purpose of this thesis is to investigate efficient calculation methods for integrals of the form I := Z ∞ −∞ e −ρv2 F(v)dv, where ρ > 0 and F is a given analytic function, and to apply these calculation methods to particular integrals of this
Alshehri, Nada
core   +1 more source

A causality-based divide-and-conquer algorithm for nonequilibrium Green’s function calculations with quantics tensor trains

SciPost Physics
We propose a causality-based divide-and-conquer algorithm for nonequilibrium Green's function calculations with quantics tensor trains. This algorithm enables stable and efficient extensions of the simulated time domain by exploiting the causality of ...
Ken Inayoshi, Maksymilian Środa, Anna Kauch, Philipp Werner, Hiroshi Shinaoka
doaj   +1 more source