Results 191 to 200 of about 127,114,064 (323)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Can plant-soil feedbacks scale up from individual species to communities: tests of the richness and biomass-ratio hypotheses. [PDF]

New Phytol
Li M, Sun Y, Siemann E, Kardol P, Xi N, Lu X.   +5 more
europepmc   +1 more source

Anticipation of Increasing Monetary Reward Selectively Recruits Nucleus Accumbens

Journal of Neuroscience, 2001
Brian Knutson, C. Adams, G. Fong, D. Hommer   +3 more
semanticscholar   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Specific leaf area modulates but does not explain the association between abiotic stress tolerance and insect feeding guild prevalence in Northern Hemisphere woody plants. [PDF]

Ann Bot
Cerdeira-Pérez A, Laanisto L, Pavanetto N, Puglielli G.   +3 more
europepmc   +1 more source

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

Nature Genetics, 2001
P. Kuehl, Jiong Zhang, Yvonne S. Lin, J. Lamba, M. Assem, J. Schuetz, P. Watkins, A. Daly, S. Wrighton, S. Hall, P. Maurel, M. Relling, Cynthia Brimer, Kazuto Yasuda, R. Venkataramanan, S. Strom, K. Thummel, M. Boguski, E. Schuetz   +18 more
semanticscholar   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

The mediating effects of home environment on the relationship between maternal BMI and childhood obesity: Findings from the ECHO-wide cohort. [PDF]

Eur J Pediatr
Haridas DN, Tartour AI, van Schayck OCP, Hahnraths MTH, Nair NS, Babu GR.   +5 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Pangenomic analyses in the cultivated grapevine confirm high genomic collinearity and extensive dispensable gene content likely involved in adaptation. [PDF]

G3 (Bethesda)
Pierre B, Bacilieri R, This D, Lacombe T, Segura V, This P, Mocoeur A, Villoutreix R, Sarah G.   +8 more
europepmc   +1 more source