Results 121 to 130 of about 127,114,064 (323)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The World and the Hereafter in Turkish-Islamic literature
, 2010 Türk İslam Edebiyatında Dünya ve Ahiret adını taşıyan tezimizde, bu sahada bulunan şairlerin dünya ve ahiret hayatına bakış açıları örneklerle ortaya koyulmuştur.
Botsalı, Saliha Görük
core
When will the imposition of the requirement to co-finance the construction of necessary facilities constitute an abuse of a dominant position? Case comment to the judgment of the Supreme Court of 5 January 2007 – Kolej Gondolowa (Ref. No. III SK 17/06) [PDF]
Yearbook of Antitrust and Regulatory Studies, 2008 The President of the Office of Competition and Consumer Protection (hereafter, UOKiK) issued on 24 March 1999 a decision (RKR-500s-01 9/98/LP-454/99) in which he refused to accept the motion lodged by Koleja Gondolowa Jaworzyna Krynicka S.A.
Konrad Kohutek
doaj
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization
Nature, 2021 D. Planas +28 more
semanticscholar +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
, 2014 77 σ.Μπορεί ο χώρος των νεκρών, όπως ένα νεκροταφείο, να αποτελεί ένα από τα σημαντικότερα σημεία μέσα στη πόλη; Η επίσκεψη σε ένα νεκροταφείο στην Ουκρανία αποτέλεσε την αφορμή για την δημιουργία των σχετικών προβληματισμών, οι οποίοι στην ουσία ...
Αναξαγόρου, Τατιάνα +1 more
core +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source