Results 151 to 160 of about 132,305,421 (291)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Spikes in the data: biological validation and applications of an assay for detecting faecal glucocorticoid metabolites in Western European hedgehogs (<i>Erinaceus europaeus</i>). [PDF]

Conserv Physiol
Harper E, Yarnell K, Palme R, Scott DM, Barber I, Yarnell RW.   +5 more
europepmc   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Psychosocial Factors Associated with Help-Seeking Intention Among Adults in Rural Japan. [PDF]

Yonago Acta Med
Takeda S, Ota M, Fujii Y, Hiroe J, Hiroe S, Kawakami M, Kishishita A, Morimoto K, Moriyasu H, Nagaishi JI, Tazumi H, Yamamoto M, Yamamoto E.   +12 more
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Bridging Programmatic Gap in Post-TB Treatment Prevention: Applying the COM-B Model and Behavior Change Wheel to Improve the Uptake of TB Preventive Therapy. [PDF]

Open Forum Infect Dis
Izudi J, Sekaggya-Wiltshire C, Kerkhoff AD, Cattamanchi A.   +3 more
europepmc   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Status of Red Cell Membrane

, 2007
The steady-state levels of #-spectrin phosphorylation in HbH (#-thalassemia 1/#-thalassemia 2), HbH/HbConstant Spring (#-thalassemia 1/HbCS, hereafter called HbH/HbCS) and nonsplenectomized #-thalassemia/HbE (hereafter called #-thal/HbE) red cells were
Protein Phosphorylation In, Prapon Wilairat, Pornpimol Metheenukul, Rutaiwan Tohtong   +3 more
core  

Research progress of small molecule targeted drugs for non-small cell lung cancer. [PDF]

Front Oncol
Qiu T, Huang X.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source