Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
LiteratureIn his poem The Rape of Lucrece, Shakespeare uses ekphrasis—the virtuosic description of a piece of art such as a painting, tapestry, or tableau—to critique the Roman ideal of female virtue.
Allison Scheidegger Reising
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
A courier service as a postal universal service – can a court asses the correctness of a legal qualification of a service of a courier company that was not contested by the company in an earlier decision taken by the postal regulator? Case comment to the judgment of the Supreme Court of 25 April 2007 – Courier services (Ref. No. III SK 2/07) [PDF]
Yearbook of Antitrust and Regulatory Studies, 2008 The President of the Polish Regulatory Office for Telecommunication and Post (hereafter, URTiP) issued in 1994 a decision prohibiting the shipping and transport company A., which was previously granted a concession for the provision of certain shipping ...
Agata Jurkowska
doaj
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
The belief of the hereafter in İslam and the reincarnation
, 2010 Kur'an'da Ölüm Sonrası ve Reenkarnasyon konusunu değişik yonlerden ele almaya, Kur'an'a göre Reenkarnasyon varmıdır, varsa ne şekilde ve nasıldır sorusuna cevap bulmaya çalışılmıştır.The blief of hereafter (Ahiret) is one of the Islam&
Sharivkhan, Galimbek
core
Belief in the hereafter in Alevi-Bektashi sources
, 2019 İnsanlık var olduğundan beri insanlar kendi mahiyetlerini sorgulamışlar ve anlamlandırmaya çalışmışlardır. Yine Tanrı yani Yaratıcı kavramı, insanın neden ve nasıl var olduğu da dünya hayatını anlamlandırması için düşündüğü meseleler olmuştur.
Tarhan, Nebi
core +1 more source