Results 61 to 70 of about 153,304,284 (204)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Belief in the hereafter in Alevi-Bektashi sources
, 2019 İnsanlık var olduğundan beri insanlar kendi mahiyetlerini sorgulamışlar ve anlamlandırmaya çalışmışlardır. Yine Tanrı yani Yaratıcı kavramı, insanın neden ve nasıl var olduğu da dünya hayatını anlamlandırması için düşündüğü meseleler olmuştur.
Tarhan, Nebi
core +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
[First para. of encyclopaedia entry]: "Atom Egoyan’s adaptation of Russell Banks’ The Sweet Hereafter treats two tragedies: a bus crash in which all but one of a community’s school-age children plunge to their deaths in icy water, and incest.
Monique Tschofen (14609600)
core +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
The Hereafter in the Context of 'Ala' al-Dawla al-Simnani's Understanding of Mystical Training
, 2019 The hereafter, one of the main pillars of Islam, has been discussed by both theologians and Sufis from various angles and interpreted in many different ways.
Kübra ZÜMRÜT ORHAN, Orhan, KÜBRA
core +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Spectacle Matters: Titanic, The Sweet Hereafter, and the Academy and Genie Awards
, 2000 In spite of the fact that, as Atom Egoyan has noted, “both The Sweet Hereafter and Titanic have big crashes with ice and water that take place halfway through the film” (qtd. in Lacey, “Tale” A2), these two films would seem to share little between them.
Gillian Roberts
core +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source