Results 161 to 170 of about 461,298 (339)

Strain-level analyses of public sequencing data to characterize <i>Escherichia coli</i> strain sharing between children and chickens in Mozambique. [PDF]

One Health
Olson N, Thystrup CAN, Smith F, Mucache H, Fafetine J, Saíde J, Mondlane-Milisse A, Brito DRA, Jesser KJ, Brown J, Hald T, Freeman M, Levy K, Nadimpalli ML.   +13 more
europepmc   +1 more source

The Nature of Questioning in the Hereafter According to the Qurʾān

Âhiret hayatına ilişkin yapılan tasvirler Kur’ân’da en yoğun şekilde işlenen konular arasında yer almaktadır. Bunun en temel sebebi, âhiret inancı ve hesap verme bilincini insanın zihin ve gönlüne yerleştirerek davranışlarının olumlu yönde değişimini ...
Kılıç, Hasan
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Unique Rational Explanations on Resurrection and the Hereafter from the Man of the Millennium

"Unique Rational Explanations on Resurrection and the Hereafter from the Man of the Millennium" by Bediüzzaman Said Nursi presents a profound exploration of resurrection and the afterlife through the lens of Islamic theology.
Hüseyin Çaksen, Khalid Hussain Mir
core   +2 more sources

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Engineering serine metabolism to enhance AOX1 promoter self-induction in formate dehydrogenase-deficient Komagataella phaffii. [PDF]

Microb Cell Fact
Cozmar R, Berrios J, Fickers P.
europepmc   +1 more source

Slavery’s Hereafter [PDF]

, 2021
openaire   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Deep critical zone controls on shallow landslides. [PDF]

Proc Natl Acad Sci U S A
Moon S, Formetta G, Higa JT, Busti R, Bellugi DG, Milledge DG, Ebel BA, Dietrich WE.   +7 more
europepmc   +1 more source