Results 71 to 80 of about 127,114,064 (323)

AMPK Activates Autophagy by Phosphorylating ULK1

Circulation Research, 2011
### Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy Egan et al Science . 2011;331:456–461. In eukaryotes, macroautophagy (hereafter, autophagy) functions as a highly conserved catabolic mechanism in ...
K. Mao, D. Klionsky
semanticscholar   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Mortal Combat and the Hereafter: saṃparāya and sāṃparāya in Sanskrit Literature

Bhasha
Sāṃparāya is a comparatively rare word in Sanskrit literature that has been translated in various ways, among them ‘battle’, ‘the next world’, and ‘transit to the next world’.
Haas, Dominik A.
doaj   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Is the parallel competence set out in Regulation 1/2003 totally clear? Case comment to the preliminary ruling of the Court of Justice of 3 May 2011 Tele 2 v Prezes Urzędu Ochrony Konkurencji i Konsumentów (Case C-375/09) [PDF]

Yearbook of Antitrust and Regulatory Studies, 2012
With a motion dated 28th of April 2005 submitted to the President of the Office of Competition and Consumer Protection (in Polish: Prezes Urzędu Ochrony Konkurencji i Konsumentów; hereafter, UOKiK President), Tele2 Polska Sp. z o.o. (currently: Netia S.A.
Ilona Szwedziak
doaj  

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

The awareness of the hereafter in terms of religious education and teaching [PDF]

, 2021
nsanın anlam arayışı hayatının hemen hemen her evresinde sürmektedir. Ölüm ve sonrasını kapsayan ahiret hayatı, bireyin bu anlam arayışında çok önemli bir konumdadır.
Akgün Özçelik, Esma
core   +1 more source

Nutritional priorities to support GLP‐1 therapy for obesity: A joint Advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society

Obesity
Glucagon‐like peptide 1 receptor agonists and combination medications (hereafter collectively referred to as GLP‐1s) are shifting the treatment landscape for obesity.
D. Mozaffarian, M. Agarwal, M. Aggarwal, Lydia C. Alexander, Caroline M. Apovian, Shagun Bindlish, Jonathan Bonnet, W. S. Butsch, Sandra Christensen, Eugenia Gianos, M. Gulati, Alka Gupta, Debbie Horn, Ryan M. Kane, Jasdeep Saluja, Deepa Sannidhi, F. C. Stanford, Emily A. Callahan   +17 more
semanticscholar   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source