Results 181 to 190 of about 461,298 (339)

Artificial intelligence (AI) psychosis: mechanisms, clinical risks and safety considerations in generative AI chatbots. [PDF]

BJPsych Open
Olisaeloka L, Nunez JJ, Vigo DV, Ng R.
europepmc   +1 more source

The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice

Nature, 2020
L. Bao, Wei Deng, Baoying Huang, Hong Gao, Jiangning Liu, L. Ren, Q. Wei, Pin Yu, Yanfeng Xu, Feifei Qi, Yajin Qu, Feng-di Li, Qi Lv, Wenling Wang, Jing Xue, Shuran Gong, Mingya Liu, Guanpeng Wang, Shunyi Wang, Zhiqi Song, Linna Zhao, Peipei Liu, Li Zhao, F. Ye, Huijuan Wang, Wei-min Zhou, N. Zhu, Wei Zhen, Haisheng Yu, Xiaojuan Zhang, Li Guo, Lan Chen, Conghui Wang, Ying Wang, Xinming Wang, Yan Xiao, Qiangming Sun, Hongqi Liu, F. Zhu, Chun-peng Ma, Lingmei Yan, Mengli Yang, Jun Han, Wenbo Xu, W. Tan, Xiaozhong Peng, Q. Jin, Guizhen Wu, Chuan Qin   +48 more
semanticscholar   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Fungal symbiosis alters non-host, community-level plant trait response to N enrichment in a low-nutrient sand dune system. [PDF]

Oecologia
Walker SL, Emery SM.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Systolic blood pressure estimation method using electrocardiogram RRI data. [PDF]

Sci Rep
Fujita E, Uchikawa R, Ogura Y, Nobuhiro Y, Maeda S, Kojima S, Maeno K, Igarashi S, Kitahara T, Tsujimura H, Taoda K, Kisaka T, Murata K, Yoshizumi M.   +13 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Multi-dimensional regulation of LIN-28 temporal expression dynamics in the C. elegans heterochronic gene cascade. [PDF]

Development
Nelson C, Ambros V.
europepmc   +1 more source

'My plundered townes, my houses devastation': the Civil War and North Midlands life, 1642-1646 [PDF]

, 1997
Bennett, M
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