Results 101 to 110 of about 3,893,972 (301)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Development of rehabilitation medicine in Slovenia and in Ljubljana

open access: yesZdravniški Vestnik, 2013
Even in ancient times, people found empirically that natural hot springs had a healing effect on ill or injured people. This knowledge was passed on through Antiquity and the Middle Ages to the present, when these discoveries have gained a scientific ...
Zvonka Zupanič Slavec, Senta Jaunig
doaj  

The history of medicine [PDF]

open access: yesWiener Medizinische Wochenschrift, 2017
Katlein, França, Torello, Lotti
openaire   +2 more sources

From the history of medicine in Nigeria [PDF]

open access: yes, 2016
Nigeria is a large country with diverse cultures and traditions. About 250 linguistic groups, of which 3 are major groups comprise over 60% of the total population. Each group evolved its own micro-culture and micro-traditions.
Blessed, B.O.
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Clinical Genetics in Britain: Origins and development [PDF]

open access: yes, 2010
Annotated and edited transcript of a Witness Seminar held on 23 September 2008. Introduction by Professor Sir John Bell, Uiversity of Oxford.First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2010.©The Trustee of the ...
Harper, PS, Reynolds, LA, Tansey, EM
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

A BRIEF HISTORY OF THE ORIGIN OF THE WORLD MEDICAL SCIENCE AND HIGH-TECH MEDICAL CARE (REVIEW)

open access: yesСеченовский вестник, 2013
The article views the history of formation of the first medical schools of ancient world and further development of medical science in the modern world. Particular attention is paid to the development of scientific component of practical medicine.
A. S. Kiselev
doaj  

Tracing embodied knowledge in the history of science and medicine: expanding the role of film in historical research

open access: yesScience Museum Group Journal
Tracing bodily knowledge in medical histories is a challenging task for researchers. Sensory, material and affective details are hard to find in archival sources and hard to put into words.
Paul Craddock, Anna Harris
doaj   +1 more source

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