Results 121 to 130 of about 1,428,010 (391)

Development of visible light‐sensitive human neuropsin (OPN5) via single amino acid substitution

open access: yesFEBS Letters, EarlyView.
The present study determines a key amino acid residue, Lys91, for defining UV sensitivity of human OPN5. Heterologous action spectroscopy of the wild type and K91 mutants of OPN5 in HEK293T cells reveals that substitution of Lys91 with neutral (alanine) or acidic amino acids (glutamic or aspartic acids) causes substantial shifts in spectral sensitivity
Yusuke Sakai   +2 more
wiley   +1 more source

China and the Humanities: At the Crossroads of the Human and the Humane [PDF]

open access: yes, 2013
This contains the sections of this volume produced by the editor, including the front matter, Preface, Introduction and Index.
openaire   +2 more sources

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

open access: yesFEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi   +5 more
wiley   +1 more source

Opening up the Humanities

open access: yesAkademisk Kvarter, 2016
Despite humanistic knowledge and methods are vital in many relationships and societal contexts, humanities are struggling to get its messages out.
Lone Dirckinck-Holmfeld
doaj   +1 more source

Claiming expertise from betwixt and between: Digital humanities librarians, emotional labor, and genre theory [PDF]

open access: yes, 2017
Librarians\u27 liminal (intermediate) position within academia situates us to make unique contributions to digital humanities (DH). In this article, we use genre theory, feminist theory, and theories of emotional labor to explore the importance of ...
Logsdon, Alexis   +2 more
core   +2 more sources

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

open access: yesFEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile   +8 more
wiley   +1 more source

Politeness in Machine-Human and Human-Human Interaction

open access: yesProceedings of the Human Factors and Ergonomics Society Annual Meeting, 2016
Computers communicate with humans in ways that increasingly resemble interactions between humans. Nuances in expression and responses to human behavior become more sophisticated, and they approach those of human-human interaction. The question arises whether we want systems eventually to behave like humans, or whether systems should, even when much ...
Meyer, Joachim   +4 more
openaire   +5 more sources

Hackathons: Why Co-Location? [PDF]

open access: yes, 2015
This research was supported by the Arts and Humanities Research Council [grant Number AH/J005142/1].This research was supported by the Arts and Humanities Research Council [grant Number AH/J005142/1].This research was supported by the Arts and Humanities
BRISCOE, G, Dima, M, Virani, TE
core  

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