Results 151 to 160 of about 1,516,008 (339)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Open Access – What’s New in the Arts & Humanities?

open access: yes, 2015
Learn about some of the newest open access publications and platforms designed to support the open sharing of humanities research. Join a discussion with librarian liaisons to arts and humanities departments about how Gettysburg faculty and the library ...
Scholarly Communications,
core  

Is UK humanities research reaching the widest possible audience? [PDF]

open access: yes, 2014
Report points to 'serious dangers for the international standing of UK research' in humanities and social sciences. Today marks the launch of another report on open access, a topic area that is rapidly becoming saturated.
Eve, Martin Paul
core  

A qualitative approach to scientific publications in the Humanities: the researchers' point of view

open access: gold, 2022
Evelyn-Paola Guillén-Chávez   +7 more
openalex   +2 more sources

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Medical Students’ Exposure to the Humanities Correlates with Positive Personal Qualities and Reduced Burnout: A Multi-Institutional U.S. Survey

open access: yesJournal of general internal medicine, 2018
S. Mangione   +10 more
semanticscholar   +1 more source

Statistical Analysis of Humanities and Social Sciences Collaboration Research in China [PDF]

open access: yes, 2006
With the development of humanities and social sciences, research collaboration becomes more and more important. This article studies collaboration phenomena of seventeen kinds of journals’ from 1995-2004 in china.
Chunlin, Jiang, Yongxia, Liang
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

open access: yesFEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom   +3 more
wiley   +1 more source

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