This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau+9 more
wiley +1 more source
Children Use the Relative Confidence of People With Conflicting Perspectives to Form Their Own Beliefs. [PDF]
Baer C, Engelmann JM, Kidd C.
europepmc +1 more source
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald+18 more
wiley +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias+12 more
wiley +1 more source
Population dynamics and digitalization: implications for COVID-19 data sources in South Africa-a scoping review. [PDF]
Akokuwebe ME+2 more
europepmc +1 more source
Correction: AlMotwaa, S.M.; Al-Otaibi, W.A. Gemcitabine-Loaded Nanocarrier of Essential Oil from <i>Pulicaria crispa</i>: Preparation, Optimization, and In Vitro Evaluation of Anticancer Activity. <i>Pharmaceutics</i> 2022, <i>14</i>, 1336. [PDF]
AlMotwaa SM, Al-Otaibi WA.
europepmc +1 more source
Spatial layout characteristics of Northern Wei Luoyang: A spatial humanities analysis of the "Record of the Monasteries of Luoyang". [PDF]
Sun R, Liu W.
europepmc +1 more source
Ordnung für die Frankfurt Graduate School for the Humanities and Social Sciences (FGS) : genehmigt durch den Beschluss des Präsidiums der Johann Wolfgang Goethe-Universität am 02. September 2008 [PDF]
Frankfurt Graduate School for the Humanities and Social Sciences
core
Disarming Dialogues during a visit to India
Ranjana Srivastava
doaj