Results 61 to 70 of about 412,360 (365)

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

open access: yesFEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt   +4 more
wiley   +1 more source

Beyond coverage : Toward a bibliometrics for the humanities

open access: yes, 2016
In this chapter, the possibility of using bibliometric measures for evaluating research in the humanities is pondered. A review of recent attempts to develop bibliometric methods for studying the humanities shows that organizational, epistemological ...
Björn Hammarfelt
semanticscholar   +1 more source

Evolutionary interplay between viruses and R‐loops

open access: yesFEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi   +4 more
wiley   +1 more source

CULTURE OF PERSONALITY PERTAINING TO THE HUMANITIES: SOCIO-PHILOSOPHICAL ASPECT

open access: yesДискурс, 2016
Culture pertaining to the humanities is associated with knowledge and exploration of human intellectual and spiritual phenomena that can help the further development of his personality and integration to the human community.
M. E. Kudryavtseva
doaj   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

open access: yesFEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt   +8 more
wiley   +1 more source

Purification tags markedly affect self‐aggregation of CPEB3

open access: yesFEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito   +6 more
wiley   +1 more source

The Rise and Fall Tool-Related Topics in CHum

open access: yesDigital Studies, 2016
What can we learn from the discourse around text tools? More than might be expected. The development of text analysis tools has been a feature of computing in the humanities since IBM supported Father Busa's production of the Index Thomisticus (Tasman ...
Amy Dyrbye   +3 more
doaj   +1 more source

Measuring impact in the humanities: Learning from accountability and economics in a contemporary history of cultural value

open access: yesPalgrave Communications, 2017
This article addresses the future of research assessment within higher education in the UK from a humanities perspective. Recent changes to policy (such as The Browne Report 2010 and the 2014 REF) indicates that humanities research is increasingly ...
Z. Bulaitis
semanticscholar   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

open access: yesFEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez   +17 more
wiley   +1 more source

Humans--a threat to humanity.

open access: yesSouth African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2008
Humanity is but a blip on the time-scale of life on earth. But that blip is all that we have, and our present global course guarantees its extinction. What are the realities? Why should the situation be of interest to medical practitioners and what should we be doing?
openaire   +4 more sources

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