Results 71 to 80 of about 412,360 (365)
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
Актуальні питання суспільних наук та історії медицини, 2014 Troyanskyy Volodymyr. Methodological Problems of Social and Humanitarian Knowledge The ambiguity of spiritual diagnoses of "spiritual illness" of Ukrainian society necessitates the deeper research in field of the humanities, methodological problems of ...
Троянський Володимир
doaj
The Encounter of Nursing and the Clinical Humanities: Nursing Education and the Spirit of Healing
Humanities, 2014 Practicing the clinical humanities requires throwing oneself into the unpredictable locus of suffering, where one is unable to infer the actual situation of the other, a process which fosters self-disclosure.
An-bang Yu
doaj +1 more source
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
Computation and the Humanities
Springer Series on Cultural Computing, 2016 This book looks at the application of computing to cultural heritage and how it is transforming how the human record can be transmitted and understood.
J. Nyhan, Andrew Flinn
semanticscholar +1 more source
FEBS Letters, EarlyView.In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi +5 more
wiley +1 more source
Humans, Humanities, and Humanism in an Age of Technology [PDF]
, 2016 Harry Potter’s world as described by J.K. Rowling in a series of books for children is not the world of us, ordinary humans.1 Owls delivering letters overnight would be handy. Howling letters that criticize their recipients in public might be embarrassing.
openaire +3 more sources
Human niche, human behaviour, human nature [PDF]
Interface Focus, 2017 The concept of a ‘human nature’ or ‘human natures’ retains a central role in theorizing about the human experience. InHomo sapiensit is clear that we have a suite of capacities generated via our evolutionary past, and present, and a flexible capacity to create and sustain particular kinds of cultures and to be shaped by them.
openaire +3 more sources
Four Claims on Research Assessment and Metric Use in the Humanities
Bulletin of the Association for Information Science and Technology, 2017 EDITOR'S SUMMARYBibliometric evaluation for research in the field of sciences can be a good way to assess the quality and factual basis of claims and can lead to more funding for authors and for research work.
Björn Hammarfelt
semanticscholar +1 more source
TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation
FEBS Letters, EarlyView.TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling +4 more
wiley +1 more source