Results 211 to 220 of about 634,520 (317)

Risk factors associated with owner‐reported sleep disturbances in Nordic horses

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Very little is known about sleep disturbances in horses, although several management or animal‐based factors may contribute to an increased risk of disturbances. Objectives To investigate factors related to rest and sleep behaviour of horses kept in stalls as perceived by Nordic horse owners or caretakers and their association with ...
H. Suomala   +4 more
wiley   +1 more source

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

open access: yesThe FEBS Journal, EarlyView.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova   +5 more
wiley   +1 more source

Prevalence and antimicrobial drug resistance of gram-negative bacteria in dairy feed and water: a One Health concern. [PDF]

open access: yesFront Vet Sci
Arbab S   +8 more
europepmc   +1 more source

Energetic stress in combination with impaired fatty acid oxidation induces sequestration of CoA and adaptation of CoA metabolism

open access: yesThe FEBS Journal, EarlyView.
Computational modelling and in vitro liver cell experiments indicate that medium‐chain acyl‐CoA dehydrogenase (MCAD) deficiency causes an accumulation of (especially medium‐chain) acyl‐CoAs at the cost of free CoA (CoASH). A substantial decrease in CoASH impairs flux through many pathways essential for energy homeostasis.
Ligia Akemi Kiyuna   +17 more
wiley   +1 more source

Cricotracheostomy for Anatomically Challenging Severe Scoliosis: A Report of Two Adult Cases. [PDF]

open access: yesCase Rep Otolaryngol
Kubo S   +8 more
europepmc   +1 more source

ON HISTORICAL (ANTI‐)REALISM

open access: yesHistory and Theory, EarlyView.
ABSTRACT The problem of historical realism has gained some new momentum recently, with a fresh challenge to what is taken to be an anti‐realist hegemony in the theory and philosophy of history. Unfortunately, this has also provided the opportunity for the reheating of old polemics and lazy scholarship that characterized the 1990s reaction to ...
João Ohara
wiley   +1 more source

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