Results 51 to 60 of about 2,158 (260)

Encapsulated Leptin‐Producing Cells Facilitate Entrainment of Circadian Rhythms in Rodents and Nonhuman Primates

open access: yesAdvanced Science, EarlyView.
A clinically translatable cell line can be engineered to produce leptin, encapsulated in biomaterial and safely implanted to produce and deliver the metabolic regulating protein within the body. Implantation of these encapsulated cells decreases the time it takes for mice and non‐human primates to adjust to circadian disruptions similar to those ...
Samantha T. Fleury   +18 more
wiley   +1 more source

Modular Metamaterials for Adaptable MRI Signal Control: Combining Dipole Array With a New Hexagon‐Based Artificial Dielectrics

open access: yesAdvanced Science, EarlyView.
A flexible, hexagonally packed artificial dielectric providing a wide range of effective permittivities (εr ≈ 30–1400) without lumped elements was developed for clinical and ultra‐high‐field MRI. Combined with modular passive‐dipole arrays, the system enables adaptable RF field shaping through electric‐ and magnetic‐dipole tuning.
Santosh Kumar Maurya   +2 more
wiley   +1 more source

dsRADAR: Imaging and Detecting Cellular dsRNA by Repurposing RNA‐Binding Proteins

open access: yesAngewandte Chemie, EarlyView.
Double‐stranded RNA (dsRNA) plays an important role in the innate immune system, but can be misregulated in disease, leading to inflammation. Despite the importance of this motif, methods for detecting dsRNA remain limited. This work shows that ADAR3 can be repurposed to provide improved detection of dsRNA, which is demonstrated in the context of viral
Weina Cheng   +7 more
wiley   +2 more sources

The Interplay of Curvature, Geometry, and Topology Shapes Tissue Organisation in Epithelial Shells

open access: yesAdvanced Science, EarlyView.
Purely geometric 3D Voronoi models predict the organisation of epithelial shells. The interplay of curvature, geometry, and topology enriches the number of pentagons in shells with lower number of cells. Small MDCK cysts and Mouse embryos match the top polygonal configurations in a compactness‐based ranking derived from the Voronoi model. In conclusion,
Laura Morato   +9 more
wiley   +1 more source

The characters of prince Myshkin by F.M. Dostoyevsky and Jeshu Ha-Nocri by M.A. Bulgakov : (an attempt at typological comparison)

open access: yesOpera slavica, 2013
The typological correlation of the "perfect heroes" in the novels "Idiot" by F. Dostoyevsky and "Master and Margarita" by M. Bulgakov manifests itself on several levels: the thematic one (the metaplot about the advent in the word of a "positively perfect
Alla Vladimirovna Zločevskaja
doaj  

Artistic features of the series of etchings of V. Efimenko for the Bulgakov’s novel «Master and Margarita»

open access: yesСучасне мистецтво, 2018
A series of etchings of the Odessa graphic artist Victor Efimenko (1933-1994) was studied for the novel by Mikhail Bulgakov «The Master and Margarita», created between 1978 and 1992.
Олена Спасскова
doaj   +1 more source

THE MEANING OF INTERTEXTUALITY OF “THE MASTER AND MARGARITA”

open access: yesBulletin of Udmurt University. Series History and Philology, 2019
The article deals with the meaning of intertextual reading of "The Master and Margarita". The text of the novel is considered as a model of counterculture, from the standpoint of which the author chooses those literary codes from which his own model of literary behavior is built. These dominant codes are manifested in the course of decoding as a result
openaire   +2 more sources

Near‐Infrared Fluorescent PROTAC Enables Theranostic Imaging and Selective Tau Degradation in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
Here, we report a novel NIR fluorescent PROTAC platform that enables real‐time imaging and targeted degradation of Alzheimer's p‐Tau. Our lead compound effectively clears p‐Tau, reduces APP/Aβ, and alleviates cognitive deficits in AD mice. This work demonstrates a theranostic strategy for visualizing degradation and developing next‐generation AD ...
Ziwei Ren   +11 more
wiley   +1 more source

Presentation and Analysis of Structural Knowledge in Learning Tasks Using the Example of a Complex Literary Text

open access: yesRUDN Journal of Psychology and Pedagogics
The lack of reliable instruments for automated assessment of learning outcomes leads to an overload of teachers who do not have sufficient resources to fully and objectively assess numerous students.
Victor M. Dozortsev   +3 more
doaj   +1 more source

Nascent Extracellular Matrix Converts Biomaterial Cues into Cell Fate Decisions

open access: yesAdvanced Science, EarlyView.
This study uncovers a tri‐directional interplay among cells, hydrogels, and their nascent extracellular matrix. Hydrogel norbornene modification alters CD44‐mediated cell–hydrogel interactions, which shape nascent matrix deposition, composition, and spatial organization.
Joshua Y. Liu   +12 more
wiley   +1 more source

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