Results 141 to 150 of about 520,483 (312)

Surgical education in the Middle Ages.

open access: yesDynamis (Granada, Spain), 2000
The new surgical texts of the thirteenth century suggest that their authors wished their subject to appear as a learned discipline, yet it was still communicated by individual practitioners privately to one or two disciples, not in a university setting. But by 1300, surgery was beginning to be taught formally as part of medicine in many Italian studia,
openaire   +5 more sources

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Vibrational Spectroscopic Analyses and Imaging of the Early Middle Ages Hemp Bast Fibres Recovered from Lake Sediments. [PDF]

open access: yesMolecules, 2021
Kalisz G   +5 more
europepmc   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

`Behold I Make All Things New': Design and Experience in Thirteenth-Century French Architecture

open access: yes, 2006
Lecture held April 5, 2006, 7 p.m. in Woodward Hall, UNM as the fifth lecture of the Institute for Medieval Studies' Spring Lecture Series 2006.The soaring architecture of the great Gothic cathedrals represents one of the outstanding technical and ...
Davis, Michael T.
core  

Archaeobotanical Geodatabase of the Early Iron Age - Early Middle Ages in the Forest Zone of the East European Plain.

open access: yes
This digital archive comprises of an archaeobotanical geodatabase, with supporting image and GIS data of the assemblages of plant macroremains from the Early Iron Age - Early Middle Ages in the forest zone of the East European ...
Julia Salova, Leonid Vyazov
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Two Masters of Surgery in Parma during the Middle Ages. [PDF]

open access: yesActa Biomed, 2020
Cervellin G   +3 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

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