Results 71 to 80 of about 314,167 (189)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

MLFLHMDA: predicting human microbe-disease association based on multi-view latent feature learning

Frontiers in Microbiology
IntroductionA growing body of research indicates that microorganisms play a crucial role in human health. Imbalances in microbial communities are closely linked to human diseases, and identifying potential relationships between microbes and diseases can ...
Ziwei Chen, Liangzhe Zhang, Jingyi Li, Mingyang Fu   +3 more
doaj   +1 more source

Land Use/Land Cover Mapping Using Multitemporal Sentinel-2 Imagery and Four Classification Methods—A Case Study from Dak Nong, Vietnam

Remote Sensing, 2020
Information on land use and land cover (LULC) including forest cover is important for the development of strategies for land planning and management. Satellite remotely sensed data of varying resolutions have been an unmatched source of such information ...
Huong Thi Thanh Nguyen, Trung Minh Doan, Erkki Tomppo, Ronald E. McRoberts   +3 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Anti-Diabetic Therapeutic Medicinal Plant Identification Using Deep Fused Discriminant Subspace Ensemble (D2SE)

International Journal of Interactive Multimedia and Artificial Intelligence
About 422 million people worldwide have diabetes, the majority living in low-and middle-income countries, and 1.5 million deaths are directly attributed to diabetes each year.
N. Sasikaladevi, S. Pradeepa, A. Revathi, S. Vimal, Gaurav Dhiman   +4 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Comparing Posture Classification: A Human Lying Posture Pressure-Map Dataset

IEEE Access
We discuss methods and algorithms for classifying the posture of a patient in their bed. The actual classification tasks are performed with a measurement chain including an in-house designed pressure mattress, a matrix of $30 \times 11$ sensing spots ...
Michal Husak, Ondrej Mihalik, Jakub Arm, Michaela Mesarosova, Vaclav Kaczmarczyk, Zdenek Bradac   +5 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

One Dimensional Median Local Binary Pattern Based Feature Extraction For Classifying Epileptic EEG Signals

Gazi Üniversitesi Fen Bilimleri Dergisi, 2017
Electroencephalogram is an important data source that widely used in detecting epilepsy. In this study, EEG records consisting of five markers A, B, C, D, E that obtained from the database of Epilogy of Bonn University Epileptology Department was used ...
Ömer Türk, Mehmet Siraç Özerdem
doaj