Results 71 to 80 of about 132,485,236 (247)

Computing Nearest Correlation Matrix via Low-Rank ODE’s Based Technique

, 2020
For n-dimensional real-valued matrix A, the computation of nearest correlation matrix; that is, a symmetric, positive semi-definite, unit diagonal and off-diagonal entries between −1 and 1 is a problem that arises in the finance industry where the ...
Jehad Alzabut, Mutti-Ur Rehman, Abodayeh, Kamaleldin, Kamaleldin Abodayeh, Rehman, Mutti-Ur, Alzabut, Jehad   +5 more
core   +1 more source

A hybrid recommendation model in social media based on deep emotion analysis and multi-source view fusion

Journal of Cloud Computing: Advances, Systems and Applications, 2020
The recommendation system is an effective means to solve the information overload problem that exists in social networks, which is also one of the most common applications of big data technology.
Liang Jiang, Lu Liu, Jingjing Yao, Leilei Shi   +3 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

The chemfp project

Journal of Cheminformatics, 2019
The chemfp project has had four main goals: (1) promote the FPS format as a text-based exchange format for dense binary cheminformatics fingerprints, (2) develop a high-performance implementation of the BitBound algorithm that could be used as an ...
Andrew Dalke
doaj   +1 more source

SPHot: Prediction of Hot Spots in Protein-RNA Complexes by Protein Sequence Information and Ensemble Classifier

IEEE Access, 2019
RNA-binding hot spots are a small and complementary set of interfacial residues that contribute most to the binding energy of protein-RNA interfaces. As experimental methods for identifying hot spots are time-consuming, labor-intensive and costly, there ...
Sijia Zhang, Le Zhao, Junfeng Xia
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Spectro-temporal post-enhancement using MMSE estimation in NMF based single-channel source separation [PDF]

, 2013
We propose to use minimum mean squared error (MMSE) estimates to enhance the signals that are separated by nonnegative matrix factorization (NMF). In single channel source separation (SCSS), NMF is used to train a set of basis vectors for each source ...
Erdoğan, Hakan, Grais, Emad Mounir, Hakan Erdogan, Emad M. Grais   +3 more
core  

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Computing the Nearest Doubly Stochastic Matrix with A Prescribed Entry [PDF]

, 2007
In this paper a nearest doubly stochastic matrix problem is studied. This problem is to ¯nd the closest doubly stochastic matrix with the prescribed (1; 1) entry to a given matrix. According to the well-established dual theory in optimization, the dual
白正简, Roger C. E. Tan, Zheng-Jian Bai, Delin Chu   +3 more
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source