Results 161 to 170 of about 128,506,783 (259)

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Prevention of Venous Thromboembolism in Patients With Pancreatic Cancer: A Nationwide Survey. [PDF]

Cancer Med
Willems RAL, Graus MUJE, van Gansewinkel EHE, van Diepen AE, Cirkel GA, van Laarhoven HWM, Wumkes ML, Homs MYV, Wilmink JW, Klok FA, van Es N, Ten Cate H, de Vos-Geelen J, Dutch Pancreatic Cancer Group (DPCG).   +13 more
europepmc   +1 more source

Chemical Strategies for Multistimuli Responsive Dynamic Covalent Materials in Regenerative Medicine

Advanced Healthcare Materials, EarlyView.
Multistimuli responsive dynamic covalent materials integrate reversible chemistry with the complex chemical, mechanical, and biochemical cues of regenerative environments. This review highlights chemical strategies based on orthogonal dynamic bonds, multicomponent networks, and hierarchical architectures to regulate mechanics, degradation, and ...
Saurabh Joshi, Matthew B. Baker, Dominik Schauenburg   +2 more
wiley   +1 more source

What happens after tapering off antipsychotics? Clinical trajectories of 267 first-episode patients who discontinued antipsychotic medication. [PDF]

World Psychiatry
de Beer F, Wijnen B, Koops S, Begemann MJH, van Beveren N, Boonstra N, Gulokusz S, de Haan L, Kikkert M, Veling W, Consortium HO, Gangadin SS, Sommer IE.   +12 more
europepmc   +1 more source

Comprehensive In Vitro Profiling Demonstrates Successful Immune Evasion of Bioengineered Immune‐Shielded Heart Valves

Advanced Healthcare Materials, EarlyView.
Living donor heart valves offer superior durability for pediatric patients but trigger immune rejection. Lentiviral delivery of viral immune‐evasion genes US2 and Serpin b9 into donor valve cells and valve tissue suppresses HLA expression, reduces PBMC clustering and cytotoxic killing, and induces transcriptional immune‐tolerance programs, paving the ...
Abraham van Wijk, Leanne Van den Berg, Isa B. M. Velraeds, Valentina Osorio Zuluaga, Emma T. M. Peereboom, Martijn J. W. E. Rabelink, Arnaud Zaldumbide, Rob C. Hoeben, Marie‐Jose T. H. Goumans, Eric Spierings, Carlijn V. C. Bouten, Marijn C. Peters   +11 more
wiley   +1 more source

Return of Research Results to Participants in Longitudinal Cohort Studies in Health Research: Findings From 24 Cohorts of the Amsterdam Cohort Hub. [PDF]

Health Expect
Qi Y, Wier MFV, Jansen F, Horst MV, Agyemang C, Balt E, Blom MMT, Brouwer C, Bosch JA, Braber AD, Chilunga FP, Davidovich U, Eikelenboom M, Gassama AA, Geerlings MI, Heijne J, Horsfall M, Huisman M, Jonkman KM, Killestein J, Klooker TK, Koopman ADM, Kramer SE, Krikeb J, Leeuwis FH, Ligthart L, Mérelle SYM, Meijs GBGM, Molenaar T, Oosterman M, van Oppen P, Paans NPG, Penninx BWJH, Rhebergen D, Rutters F, Sol Y, Spaan M, Strijbis EMM, Takkenberg GM, Tijms BM, Vijfschagt ND, Vrijkotte TGM, Visser MJ, de Geus EJC, Boot CRL, Hoogendijk EO.   +45 more
europepmc   +1 more source

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source

Detection and treatment of peritoneal metastases in colon cancer: COLOPEC trial compared to routine practice. [PDF]

Colorectal Dis
Hochstenbach I, Hamm JJM, Rademaker E, Aalbers AGJ, Boerma D, van Grevenstein WMU, Hemmer PHJ, De Hingh IHJT, Kok NFM, Tuynman JB, Madsen EVE, de Wilt JHW, Consten ECJ, van Westreenen HL, Tanis PJ, COLOPEC Collaborators Group, Dutch Snapshot Research Group and Dutch Complex Colon Cancer Initiative.   +16 more
europepmc   +1 more source

In Vivo Monitoring of Thrombo‐Inflammatory Biomarkers via Molecularly Imprinted Polymer‐Integrated Hydrogel Microneedles

Advanced Materials, EarlyView.
A wearable electrochemical microneedle patch integrates Prussian Blue redox transduction with molecularly imprinted polymer recognition for reagent‐free sampling and detection of thrombo‐inflammatory biomarkers in dermal interstitial fluid. The platform tracks thrombin and inflammatory cytokines with sensitive in vitro, ex vivo, and in vivo performance,
Mahmoud Ayman Saleh, Peyman GhavamiNejad, Arash Khorrami Jahromi, Sanjana Srikant, Sripadh Guptha Yedire, Fatemeh Keyvani, Roozbeh Siavash Moakhar, Sajad Shiekh, Mackenzie Graham, Joe Quadrilatero, Mahla Poudineh, Sara Mahshid   +11 more
wiley   +1 more source

Correction: Ultrasonography demonstrates vagus nerve atrophy in Parkinson's disease: a meta-analysis. [PDF]

J Neurol
Sijben LCJ, van Kuijk SMJ, Jahanshahi A, Mess WH, Janssen MLF.   +4 more
europepmc   +1 more source