Results 91 to 100 of about 132,986,273 (310)
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
The role of a multi-method research approach on critical research
, 2006 This paper analyses the use of a multi-method approach to research, focusing predominantly upon the need for increased criticality in management research.
Blackman, Deborah A., Fitzgerald, Anneke
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
The Complex Edge of Talent Management: A cross-disciplinary approach
, 2013 The field of Human Resource Management (HRM) has traditionally been focused on conflict resolution to the detriment of positive factors. Because of this, HRM has a reputation for being negative, and is thus perceived quite negatively. This paper draws on
Chapman, Geoffrey, Gould, Ryan
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A NEW APPROACH TO THE ASSESSMENT OF EFFECTIVE MANAGEMENT OF GAS SUPPLY DIVERSIFICATION
Baltic Journal of Economic Studies, 2017 The purpose of the paper is to study the current state and trends in the development of the basic indicators of the EU gas sector, to generalize the theoretical and methodological approaches to calculating the gas diversification factor, assess and ...
Oleh Dzoba +2 more
doaj
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
New Jersey Coastal Management Program: Assessment and Enhancement Strategy FY 2006-2010
, 2006 This document is the 2006 assessment and enhancement strategy for New Jersey's Coastal Management Program. New Jersey is required by the Federal Coastal Zone Management Act to assess its Coastal Management Program every five years and provide a strategy ...
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Understanding the very nature of Project Management : a praxiological approach [PDF]
, 2005 Foreword: In this paper I call upon a praxiological approach. Praxeology (early alteration of praxiology) is the study of human action and conduct. The name praxeology/praxiologyakes is root in praxis, Medieval Latin, from Greek, doing, action, from ...
Bredillet, Christophe
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source