Results 61 to 70 of about 1,590,388 (317)

New Approach in the Management of Vertical Root Fracture with the Help of Biodentine and CBCT

Case Reports in Dentistry, 2020
Introduction. Vertical root fracture is a big challenge to dentists for its diagnosis and treatment. As the tooth presents poor prognosis, the most common treatment modality is extraction.
H. C. Baranwal, Nidhi Singh, Neeraj Kumar, Riya Garg, Jyoti Yadav, Richik Tripathi   +5 more
doaj   +1 more source

Viable service systems and decision making in service management [PDF]

, 2012
This paper addresses decision making in the management of complex service systems, highlighting the contribution of the viable systems approach as an interpretative and governance methodology based on systems thinking.
Ng Irene C. L., M. Saviano, Polese, Francesco, Di Nauta, Primiano, F. Polese, Saviano, Marialuisa, Barile S., Barile, Sergio, I. Ng, Ng, Irene C. L., Badinelli, Ralph, Di Nauta P., Badinelli R., Badinelli, Ralph D., R. Badinelli, P. Di Nauta, Nauta, Primiano Di   +16 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

New pharmacological approaches for obesity management [PDF]

Nature Reviews Endocrinology, 2013
Obesity, which results from an imbalance between calorie intake and expenditure, now affects over 500 million individuals worldwide. Lifestyle and behavioural interventions aimed at reducing calorie intake and/or increasing energy expenditure have limited long-term effectiveness due to complex and persistent hormonal, metabolic and neurochemical ...
Rueda-Clausen, Christian F., Padwal, Raj S., Sharma, Arya M.   +2 more
openaire   +3 more sources

Biodiversity Data Management Project: Extending the Boundaries of Information Management in Collaboration with Life Scientists at the University of Otago [PDF]

, 2009
Original version of article with links updated.The Otago Biodiversity Data Management Project investigated the feasibility of managing, curating and sharing University of Otago biodiversity research data. This article discusses how the Project came about
Elliot, Gillian
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A new approach to the management of infected pacemakers [PDF]

Clinical Cardiology, 1994
AbstractManagement of infected pacemakers always presents a problem. This report describes a method of managing infected pacemakers, using the infected unit as a temporary pacer. This method has worked well in four patients.
C H, Antinori, D T, Villanueva, L, Pierucci, V J, Manuele, J A, Kuchler   +4 more
openaire   +2 more sources

Towards a path dependence approach to study management innovation [PDF]

, 2013
Purpose – Scholars in social sciences tend to use the term of path dependence without explaining exactly what they mean by it. Path dependence is a useful approach to understand the success or otherwise of the implementation of management innovation. The
Marin-Garcia, Juan A., Perello-Marin, Rosario M., Perello-Marin, M Rosario, Marcos Cuevas, Javier   +3 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source