Results 101 to 110 of about 133,687 (306)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Cytogenetics, 2019 Background This study aimed to estimate the associations of copy number variants (CNVs) with fetal kidney ultrasound anomalies. A total of 331 fetuses with kidney ultrasound anomalies who underwent prenatal chromosomal microarray analyses were enrolled ...
Shaobin Lin +7 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Taiwanese Journal of Obstetrics & Gynecology, 2019 Objective: To investigate the clinical value of chromosomal microarray analysis (CMA) in the prenatal diagnosis of genetic abnormalities in fetal isolated mild ventriculomegaly.
Hong-Lei Duan +6 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Comparison of fetal toxicity of various multi-wall carbon nanotubes in mice
Toxicology Reports, 2015 The fetal toxicities of multi-wall carbon nanotubes (MWCNTs) with various sizes were compared in CD1(ICR) mice. MWCNTs were suspended in 2% sodium carboxymethyl cellulose solution in phosphate-buffered saline.
Tomoko Fujitani +7 more
doaj +1 more source
An Ethical Evaluation of Federal Norms for Fetal Experimentation [PDF]
, 1976 Father O\u27Rourke is Director of the Medical-Moral Department of the Catholic Hospital Association in St. Louis. In this article, he raises some questions regarding the work which was done by the National Commission for the Protection of Human Subjects ...
O\u27Rourke, Kevin
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Does the risk of cerebral palsy increase or decrease with increasing gestational age?
BMC Pregnancy and Childbirth, 2003 Background It is generally accepted that the risk of cerebral palsy decreases with increasing gestational age of live born infants. However, recent studies have shown that cerebral palsy often has prenatal antecedents including congenital malformations ...
Murphy-Kaulbeck Lynn +5 more
doaj +1 more source
Variations in number and termination of the inferior thyroid veins in human fetuses.
Folia morphologica, 1998 In corrosion casts of the variations in termination of the inferior thyroid veins were investigated. The inferior thyroid veins drained into the left and right brachiocephalic veins to the superior vena cava and the internal jugular veins, and anastomosed with the thymic veins.
P, Oszukowski, H, Kosiński
openaire +1 more source