Results 111 to 120 of about 23,685,531 (292)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Speculative Fiction, the Aesthetics of Discomfort, and Muslim Futurity in Mohsin Hamid’s Exit West
IAFOR Journal of Literature & LibrarianshipFor Muslims, the future is complicated by the persistence of the past. The Islamophobia of a post-9/11 world constitutes a continuation of the historical colonial suppression of Muslim identities and epistemologies.
Netty Mattar
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Creatively hateful labelling of the “Other”: Neologisms in internet comments [PDF]
Studii de LingvisticaSo far, neologisms have been analysed in relation to hateful and aggressive content to a very limited extent and often in a fragmented manner. This paper focuses on the language of “othering” as a central component of hate speech, examining it in ...
Jūratė Ruzaitė
doaj
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The Other Sister at the MAA Annual Meeting
The Other Sister will soon be introduced to a wider audience at this year's annual meeting of the Medieval Academy of America, which will take place March 14–16 at the University of Notre Dame.
Meghan Lescault
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
, 1877 Taken from Periodical accounts relating to the foreign missions of the church of the United Brethren, Vol. XXI, Nos. CCXXII and CCXXIII with a few alterations.
Brethren's Society for the Furtherance of the Gospel.
core