Results 81 to 90 of about 23,685,531 (292)
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Skad, 2015 Varlığı Doğu ile Batının varlığı kadar eskiye dayandırılabilecek Oryantalizm disiplini temelde Doğu ve Batı dünyaları arasında hüküm sürdüğü düşünülen bir hakimiyet mücadelesi ve çatışma üzerine kurulmuştur.
Meryem Köse, Meryem Küçük
doaj
‘A Pause for Po-Ethics’: Seamus Heaney and the Ethics of Aesthetics
Humanities, 2019 In this paper, I examine the connections between ethics and aesthetics in the writing of Seamus Heaney. Looking at Heaney’s neologism of ‘po-ethics’, I move through his poetry and especially his translation of Sophocles’ ...
Eugene O’Brien
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
THE FEAR OF THE ‘OTHER’ IN THE AGE OF GLOBALIZATION. THE IMAGE OF ROMANIAN MIGRATION IN THE BRITISH PRESS [PDF]
Annals of the University of Petrosani: Economics, 2015 The present study attempts to show that, in the age of declarative cosmopolitanism and globalization, the ancestral fear of ‘the Other’ keeps resurfacing under the form of nationalism and xenophobia, very often generated and fueled by the media ...
GABRIELA DUMBRAVĂ
doaj
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source