Results 41 to 50 of about 126,880,514 (262)

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

The Linguistic Significance Of Anthroponyms And Secondary Personal Names In Political Discourse

American Journal Of Philological Sciences
In political discourse, naming practices serve not only to identify individuals but also to frame them within specific ideological or evaluative perspectives.
Sodiqova Sabohat Ilhom qizi
semanticscholar   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

PFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer

Advanced Science, EarlyView.
USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen, Zilong Wu, Yongqiang Yang, Ruoxin Fang, Huichan Xue, Rui Zhou, Gang Wu, Xiaohua Jie   +7 more
wiley   +1 more source

THE CONCEPT OF THE PROPHET IN BUILDING DOMESTIC HARMONY

Hakam: Jurnal Kajian Hukum Islam dan Hukum Ekonomi Islam
This study analyzes the Prophetic concept of building household harmony through family-related hadiths found in Sahih Bukhari and Sahih Muslim. The research is motivated by Indonesia’s high divorce rate in 2023, which reached 408,347 cases, with 251,828 ...
Muhammad Fathur Rahcman Imanda, Winning Son Ashari   +1 more
doaj   +1 more source

Cross-Cultural Examination of Cyberbullying and Cybervictimization among University Students in India and Africa: Gender, Platform, and Behavioral Disparities

International Journal for Research in Applied Science and Engineering Technology
This study investigated the prevalence, forms, and demographic correlates of cyberbullying and cybervictimization among university students in India and Africa, aiming to provide cross-cultural insights into these pervasive online phenomena.
Twisha Shah
semanticscholar   +1 more source

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

Advanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu, Ming Zhang, Yunxiang Feng, Yibo Deng, Kai Zhao, Xiangyu Li, Yun Lu, Li Tian, Tao Yang, Wei Yao, Jianming Wang, Zhengdong Deng   +11 more
wiley   +1 more source

EVOLUTION OF SURNAMES WITH THE SUFFIX -ИК (-IK) <*-IKЪ IN LOCALLY CLOSE UKRAINIAN-POLISH TERRITORIES

Polish Studies of Kyiv
The article is devoted to the study of the features of the evolution of surnames with the suffix -ик (pl. -ik) < *-ikъ in locally close Ukrainian-Polish territories.
S. Shyika
semanticscholar   +1 more source

Nicknames of the United States [PDF]

, 1982
All of these United States have nicknames, some affectionate and some at least originally derogatory. The Old Dominion is the oldest, and The Lone Star State perhaps the best-known.
Ashley, Leonard R.N.
core   +1 more source

A Unifying Thermodynamic Model for Phase Separation and Aging of Biopolymers

Advanced Science, EarlyView.
Phase separation and aging of intrinsically disordered proteins are placed in a unifying framework. A thermodynamically consistent time‐dependent version of associating‐polymer theory shows how the processes are intricately coupled. Assuming aging to occur through interacting sites resulting from reversible conformational transitions, the model ...
Jasper J. Michels, Joana Caria, Edward A. Lemke   +2 more
wiley   +1 more source