Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Contrastive learning method for leak detection in water distribution networks
npj Clean WaterDetecting and mitigating leaks in water distribution networks are vital for water conservation. Machine-learning-based (ML) acoustic leak detection models were introduced as effective alternatives for leak management.
Rongsheng Liu, Tarek Zayed, Rui Xiao
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
A comprehensive review of sustainable materials and toolpath optimization in 3D concrete printing
npj Materials SustainabilityThe construction sector has experienced remarkable advancements in recent years, driven by the demand for sustainable and efficient building practices. Among these advancements, 3D concrete printing has emerged as a highly promising technology that holds
Zicheng Zhuang +5 more
doaj +1 more source
The English Patient: Evaluating Local Lockdowns Using Real-Time COVID-19 & Consumption Data [PDF]
, 2020 John Gathergood +1 more
openalex +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Real-world Evidence of Reported Symptoms and Quality of Life Burden Associated with Chronic Rhinosinusitis with Nasal Polyposis Across Disease Severity and Region [PDF]
, 2021 S. Chen +6 more
openalex +1 more source
The special Schubert calculus is real
, 1998 We show that the Schubert calculus of enumerative geometry is real, for special Schubert conditions. That is, for any such enumerative problem, there exist real conditions for which all the a priori complex solutions are real.Comment: 5 ...
Sottile, Frank
core +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source