Results 111 to 120 of about 116,714 (299)

Adding exercise to usual care in patients with hypertension, type 2 diabetes mellitus and/or cardiovascular disease: a protocol for a systematic review with meta-analysis and trial sequential analysis

Systematic Reviews, 2019
Background Hypertension, type 2 diabetes mellitus and cardiovascular disease are among the leading causes of mortality globally. Exercise is one of the commonly recommended interventions/preventions for hypertension, type 2 diabetes mellitus and ...
Anupa Rijal, Emil Eik Nielsen, Bianca Hemmingsen, Dinesh Neupane, Peter Haulund Gæde, Michael Hecht Olsen, Janus Christian Jakobsen   +6 more
doaj   +1 more source

A systematic review and economic evaluation of exercise referral schemes in primary care: a short report [PDF]

, 2015
Background - It is estimated that only 39% of men and 29% of women in England achieve the levels of physical activity that are recommended to protect health and prevent disease. One approach to addressing this problem has been the development of exercise
Anokye, Anokye, Anokye, Briggs, Brønnum-Hansen, Campbell, Crone, Curtis, Curtis, Damush, Deci, Department of Health, Dinan, Duda, Dugdill, Edmunds, Gidlow, Gonzalez, Gusi, Halbert, Hanson, Harrison, Harrison, Health Survey for England, Health Survey for England, Higgins, Hu, Hu, Hu, Isaacs, Jackson, James, Jamrozik, Jolly, Jones, Labour Research Department, Lamb, Leijon, Lord, Martin, Miller, Moore, Morgan, Morton, Murphy, Murphy, National Institute for Health and Care Excellence (NICE), National Institute for Health and Care Excellence (NICE), National Institute for Health and Care Excellence (NICE), National Institute for Health and Care Excellence (NICE), Office for National Statistics (ONS), Orrow, Pavey, Pavey, Preis, Prochaska, Roessler, Sorensen, Sorensen, Sorensen, Sowden, Sowden, Stevens, Taylor, Taylor, Taylor, Tobi, Tobi, US Department of Health and Human Services, Ward, Ward, Williams   +71 more
core   +3 more sources

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

Advanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang, Yuchen Wang, Binbin Li, Xin Li, Chenyu Liu, Yanhao Chen, Cheng Tian, Dongmei Wang, Xiaosong Gu, Chunping Jiang, Yuda Wei, Qiurong Ding   +11 more
wiley   +1 more source

Endothelial PDGF Signaling Dysregulation Impairs Testicular Interstitial Homeostasis in Diabetes

Advanced Science, EarlyView.
Testicular endothelial cells (TECs) function as central signaling hubs that coordinate interstitial homeostasis. Diabetes disrupts TEC‐derived PDGF signaling, silences the JUND‐MCL1 survival program in Leydig cells, and impairs peritubular function, leading to fibrosis and testosterone insufficiency.
Wenxiu Zhang, Kai Hong, Yanling Tang, Lina Cui, Xiaojian Lu, Jianxing Cheng, Yangyi Fang, Qiaoling Jiang, Ziyan Zhuang, Songzhan Gao, Hui Jiang, Qiang Liu, Jingtao Guo, Zhe Zhang, Xiaoyan Wang   +14 more
wiley   +1 more source

Effects of weight loss interventions for adults who are obese on mortality, cardiovascular disease and cancer : a systematic review and meta-analysis [PDF]

, 2017
We thank Associate Professor Andrew Grey for helping to resolve discrepancies in data extraction and interpretation for cardiovascular events and cancer events.
Avenell, Alison, Bolland, Mark, Fraser, Cynthia, Hudson, Jemma, Ma, Chenhan, MacLennan, Graeme, Robertson, Clare, Sharma, Pawana, Stewart, Fiona   +8 more
core   +2 more sources

Short-term effects of a pay-for-performance programme for diabetes in a primary care setting: an observational study

Scandinavian Journal of Primary Health Care, 2015
Objective A pay-for-performance (P4P) programme for primary care was introduced in 2011 by a Swedish county (with 1.6 million inhabitants). Effects on register entry practice and comparability of data for patients with diabetes mellitus were assessed ...
H. Ödesjö, A. Anell, S. Gudbjörnsdottir, J. Thorn, S. Björck   +4 more
doaj   +1 more source

Evaluating tools to support a new practical classification of diabetes: excellent control may represent misdiagnosis and omission from disease registers is associated with worse control. [PDF]

, 2012
To conduct a service evaluation of usability and utility on-line clinical audit tools developed as part of a UK Classification of Diabetes project to improve the categorisation and ultimately management of ...
de Lusignan, S, Desombre, T, Hassan Sadek, N, Khunti, K, Sadek, AR, Tahir, A   +5 more
core   +2 more sources

Extracellular Vesicles in Autoimmune Diseases: From Diagnostic Biomarkers to Engineered Therapeutics

Advanced Science, EarlyView.
This review provides a systematic comparison of extracellular vesicles (EVs) from both mammalian and plant sources in the context of autoimmune diseases. It highlights their emerging roles as precision biomarkers and engineered therapeutic platforms.
Yufei Wu, Huiyuan Ma, Tinghui Zhu, Shuwei Huang, Manxi Lu, Qiong Wang, Zai‐Long Chi   +6 more
wiley   +1 more source

Dietary total antioxidant capacity and risk of prediabetes and diabetes mellitus: a systematic review and dose-response meta-analysis of 170,919 participants

Frontiers in Nutrition
BackgroundObservational studies have assessed the association between total antioxidant capacity of the diet and risk of diabetes mellitus. However, results from these studies were not entirely consistent.
Ruomeng Li, Long Shu, Qin Zhu, Qin Zhu, Dan Lu   +4 more
doaj   +1 more source

Multi‐Tissue Omics Analysis Uncovers Translational Regulation Underlying Complex Traits in Pigs

Advanced Science, EarlyView.
Integrated multi‐omics across pig breeds and tissues reveals key principles of post‐transcriptional translational regulation and their contribution to trait formation. A gene network framework integrating transcriptomic and translatomic data is developed and applied to elucidate the genetic basis of meat production, offering new insights into mammalian
Chao Wang, Yuanyuan Zhang, Choulin Chen, Xiaoxian Xu, Shenghua Qin, Junyan Qi, Yongzhou Bao, Huiming Li, Ruipu Chen, Weigang Zheng, Zhilong Chen, Lingzhao Fang, Yunxiang Zhao, Yuwen Liu   +13 more
wiley   +1 more source