Results 41 to 50 of about 873,948 (255)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Distributed Adaptive Affine Formation Control for Heterogeneous Linear Networked Systems
IEEE Access, 2019 This paper addresses the distributed adaptive affine formation protocol design problem for the heterogeneous leader-follower-type linear networked systems, in which the interaction graph is directed.
Yang Xu +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Enriched continuum for multi-scale transient diffusion coupled to mechanics
Advanced Modeling and Simulation in Engineering Sciences, 2020 In this article, we present a computationally efficient homogenization technique for linear coupled diffusion–mechanics problems. It considers a linear chemo-mechanical material model at the fine scale, and relies on a full separation of scales between ...
Abdullah Waseem +4 more
doaj +1 more source
Deep Metric Learning with Angular Loss
, 2017 The modern image search system requires semantic understanding of image, and a key yet under-addressed problem is to learn a good metric for measuring the similarity between images.
Lin, Yuanqing +4 more
core +1 more source
Environmental public good provision under robust decision making [PDF]
, 2016 We study public good provision in a two-country dynamic setup with environmental externalities. In this framework, we examine robust decision making under potential misspecification of the process that describes the evolution of the environmental ...
Angelopoulos, Konstantinos +2 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
The Improving Efficiency Measurement and Discriminating Power in the DEA Models with Presentation of a new Model of CSW [PDF]
بهبود مدیریت, 2013 Data Envelopment Analysis (DEA) is a wide range of mathematical models for measuring the relative efficiencies of a set of Decision Making Units (DMUS) that use similar inputs to produce similar outputs.
Adel Azar, Mohammad Zareei Mohmood Abadi
doaj
Stochastic User Equilibrium and Value-of-time Analysis with Reference-dependent Route Choice
European Journal of Transport and Infrastructure Research, 2011 Reference-dependent theory of riskless choice assumes that carriers of utility are gains and losses relative to a reference point and that individuals are loss averse, i.e. losses are valued more highly than gains.
Paolo Delle Site, Francesco Filippi
doaj +1 more source