Results 21 to 30 of about 836,888 (261)

Networking in the Republic of Letters: Magliabechi and the Dutch Republic

The Journal of Interdisciplinary History, 2022
Abstract The brokers who forge networks have exclusive access to diverse and innovative information. Hence, many histories of the Republic of Letters (1500–1800) stress the importance of brokers for the circulation and development of new ideas.
openaire   +2 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Chinese Guidelines for the Clinical Management of Obesity (2024 Edition)

Xiehe Yixue Zazhi
Obesity serves as a significant contributing factor to various chronic diseases, so standardized and systematic clinical management of obesity is crucial for enhancing overall health outcomes. Currently, there is a lack of comprehensive and authoritative
Department of Medical Administration, National Health Commission of the People's Republic of China
doaj   +1 more source

The Anthropocene and the republic [PDF]

Critical Review of International Social and Political Philosophy, 2019
The Anthropocene, understood from the perspective of the creators of Earth System Science and IPCC, calls for global governance, which tends to be understood as an epistocratic, technocratic affair...
openaire   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Guidelines for the Diagnosis and Treatment of Primary Liver Cancer(2026 Edition)

Xiehe Yixue Zazhi
The Guidelines for the Diagnosis and Treatment of Primary Liver Cancer(2026 Edition) were officially finalized and released in April 2026, representing the most up-to-date national guidance for liver cancer management in China.
Department of Medical Administration, National Health Commission of the People's Republic of China
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Clinical Practice Guideline for Primary Liver Cancer(2024 Edition)

Xiehe Yixue Zazhi
Primary liver cancer is one of the common malignant tumors in China. According to the cancer statistics report in China for the year 2022, the incidence and mortality rates of primary liver cancer in our country rank 5th and 2nd, with 367 700 new cases ...
Department of Medical Administration, National Health Commission of the People's Republic of China
doaj   +1 more source

Foreign policy conditionality of the Slovak Republic [PDF]

Annales Scientia Politica, 2023
On January 1, 1993, as a result of the breakup of the Czech and Slovak Federative Republics, a new state was created on the political map of Europe: the Slovak Republic.
Krzysztof Żarna
doaj