Results 131 to 140 of about 136,752 (325)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright   +10 more
wiley   +1 more source

Global Rather Than Vertical‐Selective Saccadic Abnormalities in Progressive Supranuclear Palsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To test whether vertical saccades are preferentially affected in Progressive Supranuclear Palsy (PSP). Methods PSP patients (n = 24) were compared to age‐matched controls (n = 94) and two degenerative groups (Alzheimer's disease, n = 20; Lewy body disease, n = 50).
Duy Duan Nguyen   +6 more
wiley   +1 more source

Continuous Recording of Social Housing Sales (CORE), 2007/08-2021/22: Special Licence Access [PDF]

open access: yes
copyright UK Data Service and data collection copyright owner.The COntinuous REcording of Lettings and Sales (CORE) is a national information source that provides annual official statistics on new lettings and sales of social housing stock.
Ministry of Housing, Communities and Local Government
core  

Universal Claims: tenants’ campaigns for tenure neutrality and a general needs model of social housing [PDF]

open access: yes, 2014
The policy of tenure neutrality championed by the International Union of Tenants advances a model of general needs or universal social rented housing provision unrestricted by income limits or needs-based rationing.
Bradley, Q
core  

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay   +15 more
wiley   +1 more source

Continuous Recording of Social Housing Sales (CORE), 2007/08-2021/22: Secure Access [PDF]

open access: yes
copyright UK Data Service and data collection copyright owner.The COntinuous REcording of Lettings and Sales (CORE) is a national information source that provides annual official statistics on new lettings and sales of social housing stock.
Department for Levelling Up, Housing and Communities
core  

Towards a housing policy that accommodates children : a study of entitlements and entitlement failures in the National Housing Subsidy Scheme [PDF]

open access: yes, 2010
Includes bibliographical references (leaves 135-141).This research is about a targeted response to poverty. The poverty alleviation programme in question is the South African National Housing Subsidy Scheme, and the thesis aims to bring together issues ...
Hall, Katharine
core  

Evaluation of Dried Plasma Spot‐Based Quantification of Glial Fibrillary Acidic Protein as a Disease‐Associated Biomarker in Neuromyelitis Optica Spectrum Disorder

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the diagnostic accuracy of glial fibrillary acidic protein (GFAP) measured in dried plasma spots versus conventional plasma‐ and serum‐GFAP testing for assessment of disease severity in aquaporin‐4 immunoglobulin G–positive neuromyelitis optica spectrum disorder (AQP4‐IgG+ NMOSD).
Felix Wohlrab   +19 more
wiley   +1 more source

Continuous Recording of Social Housing Sales (CORE), 2007/08-2021/22 [PDF]

open access: yes
copyright UK Data Service and data collection copyright owner.The COntinuous REcording of Lettings and Sales (CORE) is a national information source that provides annual official statistics on new lettings and sales of social housing stock.
Ministry of Housing, Communities and Local Government
core  

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