Results 201 to 210 of about 472,928 (268)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Six Cases of Borealpox and Evidence of a Zoonotic Source: Alaska, 2020-2023. [PDF]

Clin Infect Dis
Mooring EQ, Rogers J, Whitehill F, Werle Z, Gigante CM, Matheny A, Conley C, Westley BP, Kunkel A, Newell KG, Minhaj FS, Li Y, Morgan CN, Wilkins K, Davidson W, Nakazawa Y, McCollum AM, Olson V, Petersen BW, Castrodale LJ, Olson LE, Gunderson AM, Doty JB, McLaughlin JB.   +23 more
europepmc   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

On using clustering statistics for assessing plasmid binning tools accuracy. [PDF]

Brief Bioinform
Epain V, Mane A, Chauve C.
europepmc   +1 more source

Inverse multi-principal element alloys design via conditional wasserstein generative adversarial network. [PDF]

Sci Rep
Acquah Forson C, Gerashi E, Zhao Y, Hatefi A, Alidokht SA.   +4 more
europepmc   +1 more source

A comprehensive dataset for uncovering housing price drivers in emerging cities: Nanning as a case study. [PDF]

Data Brief
Lin W, Wu K, Zhang X, Gu X, Jiang M, Wang J, Han F.   +6 more
europepmc   +1 more source

Multilevel DFT Response Theory. [PDF]

J Chem Theory Comput
Barlini A, Bloino J, Koch H, Giovannini T.   +3 more
europepmc   +1 more source

Symptom severity, neighborhood crime, and neural correlates of reappraisal in patients with major depression and social anxiety. [PDF]

Psychol Med
Feurer C, Jimmy J, Uribe M, Burkhouse KL, Shankman SA, Phan KL, Ajilore O, Klumpp H.   +7 more
europepmc   +1 more source

Parabolic PDEs with Dynamic Data under a Bounded Slope Condition. [PDF]

Arch Ration Mech Anal
Bögelein V, Duzaar F, Treu G.
europepmc   +1 more source