Results 41 to 50 of about 41,488 (264)

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

P.D.Baranovsky. Unknown Pages in the Protection of Architectural Monuments of the Russian North (1920-1970)

Academia: Архитектура и строительство, 2018
This article explores views of Petr Baranovsky (1892-1984), well-known preservationist and architectural conservator, about issues concerning the protection of architectural monuments of the Russian North. In the 1920s P.D. Baranovsky organized the first
Vladimir A. Tsvetnov
doaj   +1 more source

Whole‐Genome Sequencing Pilot of the Central Asian Genomic Diversity Project Reveals Distinct Histories, Adaptation, and Introgression

Advanced Science, EarlyView.
As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Lintao Luo, Jie Zhong, Zhaxylyk Sabitov, CAGDP Consortium†, Lan‐Hai Wei, Chao Liu, Maxat Zhabagin, Guanglin He   +11 more
wiley   +1 more source

THE EARLIEST EVIDENCE OF THE MANUFACTURING OF SOLUTIONS AND VISCOPLASTIC MIXTURES FROM PAINT PIGMENTS ON THE RUSSIAN PLAIN IN THE MIDDLE PALEOLITHIC

Нижневолжский археологический вестник
The article presents the results of studying a series of small individual pigment particles discovered in the cultural layer of the Chelyuskinets II site, which is part of the Lower Volga Middle Paleolithic group together with the Eurasian ...
Maria Zheltova, Maria Komagorova, Yulia Anisovets, Vladislav Zhitenev, Darya Ulyanova, Redzhep Kurbanov, Ksenia Stepanova, Anton Anoykin, Yaroslav Ivanov, Vasilisa Smolkina, Evgeniy Kazakov, Stanislav Remizov, Aleksander Otcherednoy   +12 more
doaj   +1 more source

A Disulfide‐Sticker Strategy for Marine Adhesive Coatings: From Deciphering Self‐Assembly Mechanism to Functional Application in Hair Regeneration

Advanced Science, EarlyView.
A disulfide‐sticker strategy, coupled with Ca2+ coordination, drives the hierarchical self‐assembly of a recombinant scallop adhesive protein into fishnet‐like nanostructures, affording a coating with versatile wet adhesion and intrinsic antioxidant activity. This biocompatible coating markedly promotes hair regeneration by activating follicular niches,
Lulu Wang, Juan Yang, Xin Jiang, Zhanghui Zheng, Hongyu Wei, Na Li, Xiangqiang Chu, Weizhi Liu   +7 more
wiley   +1 more source

New Data on the Middle Paleolithic Site Chelyuskinets II (Based on 2024 Fieldwork Results)

Нижневолжский археологический вестник
The article presents the results of field work of the Lower Volga Paleolithic Expedition of the Institute of Archaeology and Ethnography of the Russian Academy of Sciences, Siberian Branch, organized within the framework of the integrated Lower Volga ...
Aleksander K. Otcherednoy, Stanislav O. Remizov, Yaroslav D. Ivanov, Vasilisa S. Smolkina, Ekaterina M. Kezina, Redzhep N. Kurbanov, Idris A. Idrisov   +6 more
doaj   +1 more source

RGS16 Aggravates Hepatic Ischemia‐Reperfusion Injury via Hepatocyte‐Intrinsic Apoptosis/Inflammation & Neutrophil Recruitment/NETosis

Advanced Science, EarlyView.
RGS16 competitively interferes with the YTHDF3–PAN3 complex to prevent CXCL1 mRNA decay during hepatic ischemia‐reperfusion injury. Stabilized CXCL1 strengthens hepatocyte injury, neutrophil recruitment, and NET‐associated inflammation, uncovering how stress‐induced RGS16 converts post‐transcriptional regulation into immune‐mediated liver damage ...
Xinglong Li, Zhanzhi Meng, Hongjun Yu, Yongliang Hua, Zihao Li, Bing Yin, Baolin Qian, Zhongyu Li, Yongzhi Zhou, Zhigang Feng, Shounan Lu, Shanjia Ke, Miaoyu Bai, Yao Fu, Wei Tang, Natalia V. Belosludtseva, Yong Ma   +16 more
wiley   +1 more source

Traceability of Agri‐Food Products: The Key to Conscious Trade

Agribusiness, EarlyView.
ABSTRACT Globalization and growing concerns about sustainability have led to improvements in product traceability, quality, and sustainability. Traceability contributes to environmental protection and supports sustainable development by fostering transparency in agricultural practices and encouraging the responsible use of resources.
Scarlett Queen Almeida Bispo, Fernanda Aparecida Silva, Michelle Márcia Viana Martins, Marcelo José Braga Nonnenberg, Ruan da Silva Vianna, Carla Cristina Passos Cruz   +5 more
wiley   +1 more source

Parasites provide evidence for fish consumption among Iron Age Siberian pastoralists

Scientific Reports
The subsistence economies of prehistoric pastoralists of the Eurasian steppes have long been viewed through an oversimplified model of reliance on domesticated animals.
Sergey Slepchenko, Timur Sadykov, Daria Fomicheva, Jegor Blochin, Gino Caspari   +4 more
doaj   +1 more source

The influence of Soviet Union on the post-war culture development of Eastern Germany (1945-1949)

Вестник Тамбовского университета. Серия: Гуманитарные науки, 2019
The study of cultural problems in the countries of the socialist community has acquired considerable relevance in historical research recently. At the same time there are considerable gaps in the study of culture of German Democratic Republic.
V. V. Nefedov
doaj   +1 more source