Results 181 to 190 of about 755 (223)

USP5‐C‐MAF Axis Regulates Autophagy‐Dependent Neuronal Ferroptosis in Spinal Cord Injury Therapeutics

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
SCI induces significant upregulation of USP5 in neurons. The overexpressed USP5 stabilizes c‐MAF protein expression through its deubiquitinase activity, activating autophagy and accelerating the degradation of autophagic ferritin, thereby mediating neuronal ferroptosis. This ultimately leads to impaired functional recovery in SCI mice.
Shiyang Weng   +4 more
wiley   +1 more source

Genetic Bone Diseases: A Scoping Review of Pathology, Symptoms, Diagnosis, Treatment, and New Horizons

open access: yesAdvanced Genetics, Volume 7, Issue 2, June 2026.
This review highlights six genetic diseases of the bone, aiming to provide clinicians and researchers with updated information on their diagnosis and treatment. It also includes an assessment of common clinical and radiographic findings, along with pathophysiology related to diseases.
Colin Jones, Ambalangodage C. Jayasuriya
wiley   +1 more source

In Vivo Assessment of Distal Femur Fracture Motion via Weightbearing CT

open access: yesJournal of Orthopaedic Research, Volume 44, Issue 6, June 2026.
ABSTRACT Distal femur fractures have a significant risk of healing complications, with potentially suboptimal fracture motion. We developed an in vivo method of quantifying fracture motion to support translational research. Five men and one woman (age 48.3 ± 24.9 years; weight 79.8 ± 12.9 kg, mean ± SD) underwent non‐weightbearing and weightbearing CT ...
William D. Lack   +5 more
wiley   +1 more source

USP54 Promotes Ferroptosis in Non‐Small Cell Lung Cancer by Mediating FOXA2 Deubiquitination and Enhancing ACSL4 Transcription

open access: yesThe Kaohsiung Journal of Medical Sciences, Volume 42, Issue 6, June 2026.
ABSTRACT Non‐small cell lung cancer (NSCLC) is the most common type of lung cancer, with a 5‐year survival rate of less than 20% and a high risk of recurrence despite advances in treatment. This study aimed to identify new therapeutic targets to increase the effectiveness of NSCLC treatments.
Rui‐Shi Wei   +5 more
wiley   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

open access: yesMedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang   +14 more
wiley   +1 more source

High Value‐Added Secondary Raw Material From Winemaking Waste Bentonite to Design Antioxidant Pectin‐Based Mucoadhesive Buccal Films

open access: yesChemistryOpen, Volume 15, Issue 6, June 2026.
Hyaluronic acid and/or pectin (crosslinked by calcium lactate) allowed the development of Bentophen200 extract‐loaded buccal films. Given i) the antioxidant power of the polyphenols‐rich extract optimized via multiple maceration of waste bentonite and ii) the flexibility, mucoadhesivity, and suitability of the films for oromucosal application, they can
Giulia Di Prima   +2 more
wiley   +1 more source

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