SCI induces significant upregulation of USP5 in neurons. The overexpressed USP5 stabilizes c‐MAF protein expression through its deubiquitinase activity, activating autophagy and accelerating the degradation of autophagic ferritin, thereby mediating neuronal ferroptosis. This ultimately leads to impaired functional recovery in SCI mice.
Shiyang Weng +4 more
wiley +1 more source
This review highlights six genetic diseases of the bone, aiming to provide clinicians and researchers with updated information on their diagnosis and treatment. It also includes an assessment of common clinical and radiographic findings, along with pathophysiology related to diseases.
Colin Jones, Ambalangodage C. Jayasuriya
wiley +1 more source
The effects of school bullying victimization on the development of adolescent depression across genders: a hierarchical linear model analysis. [PDF]
Liu L +9 more
europepmc +1 more source
In Vivo Assessment of Distal Femur Fracture Motion via Weightbearing CT
ABSTRACT Distal femur fractures have a significant risk of healing complications, with potentially suboptimal fracture motion. We developed an in vivo method of quantifying fracture motion to support translational research. Five men and one woman (age 48.3 ± 24.9 years; weight 79.8 ± 12.9 kg, mean ± SD) underwent non‐weightbearing and weightbearing CT ...
William D. Lack +5 more
wiley +1 more source
Factors Influencing Engagement in a Digital Substance Use Prevention Program: Qualitative Study Using the Capability, Opportunity, Motivation Model and Theoretical Domains Framework. [PDF]
Kiselev N +5 more
europepmc +1 more source
ABSTRACT Non‐small cell lung cancer (NSCLC) is the most common type of lung cancer, with a 5‐year survival rate of less than 20% and a high risk of recurrence despite advances in treatment. This study aimed to identify new therapeutic targets to increase the effectiveness of NSCLC treatments.
Rui‐Shi Wei +5 more
wiley +1 more source
Relationship between perceived school climate and adolescent aggressive behavior: a moderated mediation model. [PDF]
Wen L, He F, Jiang Y, Tong L.
europepmc +1 more source
Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang +14 more
wiley +1 more source
Validation of the moral foundations questionnaire-2 (MFQ-2) in Germany: Psychometric properties and associations with political ideology, religiosity, and personality. [PDF]
Musa NS, Müller SM, Hopp FR.
europepmc +1 more source
Hyaluronic acid and/or pectin (crosslinked by calcium lactate) allowed the development of Bentophen200 extract‐loaded buccal films. Given i) the antioxidant power of the polyphenols‐rich extract optimized via multiple maceration of waste bentonite and ii) the flexibility, mucoadhesivity, and suitability of the films for oromucosal application, they can
Giulia Di Prima +2 more
wiley +1 more source

