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Indigenous Knowledge in Acholi Nicknames [PDF]

open access: yes, 2017
Rationale of Study – Nicknames are a cultural experience. In some contexts, they are perceived as ‘little’ names that are different from ‘official’ names. Therefore, a nickname is a part of personal identity.
J.P. Odoch Pido
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

open access: yesMolecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna   +8 more
wiley   +1 more source

ANTHROPONYMS IN P. BELYANSKY'S NOVEL “FIGHT YOU CANNOT RETREAT”: STRUCTURAL-FUNCTIONAL AND SEMANTIC ASPECTS

open access: yesФілологічні трактати
This article is devoted to a comprehensive linguistic analysis of the anthroponymic space in P. Belyansky’s novel ‘Fight You Cannot Retreat’ (2024), which is considered a prime example of contemporary Ukrainian military prose.
Mariana Markovska
doaj   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li   +15 more
wiley   +1 more source

Innovative artifacts of the unofficial anthroponymicon of Ukrainian politics in the contemporary metamodern discourse

open access: yesВісник Харківського національного університету імені В. Н. Каразіна. Серія Філологія. Vìsnik Harkìvsʹkogo nacìonalʹnogo unìversitetu ìmenì V.N. Karazìna. Serìâ Fìlologìâ.
The article is devoted to the study of current trends in unofficial naming, especially neogenic derivative processes. The author aims to explore innovative artifacts of the unofficial anthroponymicon of Ukrainian politics from the perspective of ...
Kateryna Diukar
doaj   +1 more source

USP30‐Mediated Deubiquitination of PEX5 Suppresses Pexophagy to Drive Tubular Injury in Diabetic Kidney Disease

open access: yesAdvanced Science, EarlyView.
USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Jia Li   +10 more
wiley   +1 more source

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling

open access: yesAdvanced Science, EarlyView.
Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Fangzi Zha   +13 more
wiley   +1 more source

Modern everyday nicknames in Sweden

open access: yes, 2016
The aim of the study is to examine the modern everyday use of nicknames. The study is based on two different types of material – questionnaires and interviews.
Gustavsson, Linnea
core   +2 more sources

THE CONCEPT OF THE PROPHET IN BUILDING DOMESTIC HARMONY

open access: yesHakam: Jurnal Kajian Hukum Islam dan Hukum Ekonomi Islam
This study analyzes the Prophetic concept of building household harmony through family-related hadiths found in Sahih Bukhari and Sahih Muslim. The research is motivated by Indonesia’s high divorce rate in 2023, which reached 408,347 cases, with 251,828 ...
Muhammad Fathur Rahcman Imanda   +1 more
doaj   +1 more source

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