Results 141 to 150 of about 856,418 (259)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A standardized approach to test missense <i>PNPLA1</i> rare genetic variants of uncertain significance in epidermal differentiation disorders. [PDF]

JID Innov
Pell N, Bernard P, Courrech S, Opalka L, Millán-Sánchez A, Levy E, Garnier S, Clément C, Le Faouder P, Vávrová K, López O, Bertrand-Michel J, Leprince C, Fourquaux I, Mejia JE, Pagès JC, Mazereeuw-Hautier J, Jonca N.   +17 more
europepmc   +1 more source

A novel standardized approach for the 3D evaluation of upper eyelid area and volume. [PDF]

Quant Imaging Med Surg, 2023
Guo Y, Rokohl AC, Fan W, Theodosiou R, Li X, Lou L, Gao T, Lin M, Yao K, Heindl LM.   +9 more
europepmc   +1 more source

982Pediatric Central Line Maintenance Bundle – Standardizing the Approach [PDF]

Open Forum Infectious Diseases, 2014
Karcz, Adam, Kelley, Kristen, Bogue, Terri, Cox, Elaine   +3 more
openaire   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Cardiopulmonary Exercise Testing in the Prognostic Assessment of Heart Failure: From a Standardized Approach to Tailored Therapeutic Strategies. [PDF]

Medicina (Kaunas)
Puttini F, Pezzuto B, Vignati C.
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Cell Line-Based Human Bladder Organoids with Bladder-like Self-Organization-A New Standardized Approach in Bladder Cancer Research. [PDF]

Biomedicines, 2023
Berndt-Paetz M, Han S, Weimann A, Reinhold A, Nürnberger S, Neuhaus J.   +5 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Standardized approach to small bowel bleeding in a hierarchical healthcare network with varying levels of complexity. [PDF]

Arq Bras Cir Dig
Carvalho RP, Gama-Cunha G, Martinez EZ, Santos JSD.   +3 more
europepmc   +1 more source