Results 21 to 30 of about 547 (205)
Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors
Advanced Science, EarlyView.This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng +12 more
wiley +1 more source
Photocatalytic Synthesis of Pentafluorosulfanyl Ketones, Acetals, and BCP Motifs Utilizing SF6
Advanced Science, EarlyView.A photocatalytic single electron reduction strategy is reported for the activation and valorization of sulfur hexafluoride (SF6), a potent greenhouse gas. Under mild conditions, SF6 is reduced to generate pentafluorosulfanyl (SF5) radicals, enabling direct access to pentafluorosulfanyl ketones, acetals, and BCP motifs.
Chen‐Hui Jiang +11 more
wiley +1 more source
Advanced Science, EarlyView.Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim +2 more
wiley +1 more source
INDIVIDUAL NICKNAMES, MOTIVATED BY FEATURES OF RELATIVES AND FAMILY MEMBERS BEHAVIOR (BASED ON THE ANTHROPONYMIC MATERIAL OF TERNOPIL REGION) [PDF]
, 2018 В статье на материале неофициальной антропонимии Тернопольщины проанализирована группа индивидуальных прозвищ, мотивированных особенностями родственников носителя.
Вербовецька, О. С.
core
Advanced Intelligent Discovery, EarlyView.This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng +4 more
wiley +1 more source
THE SPECIFICS OF TRANSLATING THE FICTIONAL LANGUAGE "NADSAT" INTO FRENCH
Sovremennye Issledovaniâ Socialʹnyh ProblemBackground. One of the most striking examples of the use of a fictional language in fiction is Anthony Burgess's novel A Clockwork Orange, in which the author creates a unique "conlang" known as "nadsat". The relevance of the study is due to the need for
Margarita N. Sadovnikova
doaj +1 more source
Journal of Behçet Uz Children's HospitalObjective: This study aims to examine how structural, social, and economic inequalities influence the rights of children with disabilities to access, participate, and be protected in digital environments in Türkiye.
Emine Gök +4 more
doaj +1 more source
Semiotic Analysis of Proper Names and Nicknames of Human Beings (On the Example of Two Villages)
, 2020 The specifics of proper names are indicated by their semantics and structural features, namely, the absence of a plural number existence, the derivation of conjugation forms.
ტურაშვილი, მარინე
core
Veliuonos apylinkių pravardžių struktūros ypatumai: antrinės pravardės
, 2014 The paper analyses 782 nicknames that were recorded at Veliuona vicinity during the project of the Institute of the Lithuanian Language “Modern Research of Geolinguistics in Lithuania: Optimisation of Network of Points and Interactive Spread of
Rita Baranauskienė +5 more
core +1 more source
Toward Chromoselective Transformations in Biological Systems: Perspectives and Challenges
Angewandte Chemie International Edition, EarlyView.Controlling biological systems with small‐molecule chromophores has evolved into a powerful strategy and is applied from chemical biology to medicine. However, the complexity of in vivo systems cannot be matched by a single wavelength of light. Developing methods to combine and individually control multiple chromophores is crucial.
Nadja A. Simeth
wiley +1 more source