Results 41 to 50 of about 4,189,816 (303)
Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer
FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose +11 morewiley +1 more sourceMicroglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures
FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling +6 morewiley +1 more sourceDetection of the temporal variation of the sun's cosmic ray shadow with the IceCube detector [PDF]
, 2018 We report on the observation of a deficit in the cosmic ray flux from the directions of the Moon and Sun with five years of data taken by the IceCube Neutrino Observatory.Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Argüelles, C., Auffenberg, Jan, Axani, S., Backes, P., Bagherpour, H., Bai, X., Barbano, A., Barron, J. P., Barwick, S. W., Baum, V., Bay, R., Beatty, J. J., Becker Tjus, J., Becker, K.-H., BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bohm, C., Bos, F., Botner, O., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Bretz, H.-P., Bron, S., Brostean-Kaiser, J., Burgman, A., Busse, R. S., Börner, M., Böser, S., Carver, T., Chen, C., Cheung, E., Chirkin, D., Clark, K., Classen, L., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., Day, M., de André, J. P. A. M., De Clercq, C., De Ridder, S., de Vries, K. D., de Wasseige, G., de With, M., DeLaunay, J. J., Dembinski, H., Deoskar, K., Desiati, P., DeYoung, T., Dujmovic, H., Dunkman, M., Dvorak, E., Díaz-Vélez, J. C., Eberhardt, B., Ehrhardt, T., Eichmann, B., Eller, P., Evenson, P. A., Fahey, S., Fazely, A. R., Felde, J., Filimonov, K., Finley, C., Franckowiak, A., Friedman, E., Fritz, A., Gaisser, T. K., Gallagher, J., Ganster, Erik, Garrappa, S., Gerhardt, L., Ghorbani, K., Giang, W., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Grant, D., Griffith, Z., Haack, Christian, Hallgren, A., Halve, Lasse Yannik, Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Helbing, K., Hellauer, R., Hickford, S., Hignight, J., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Huber, M., Hultqvist, K., Hussain, R., Hünnefeld, M., IceCube Collaboration, In, S., Iovine, N., Ishihara, A., Jacobi, E., Japaridze, G. S., Jeong, M., Jero, K., Jones, B. J. P., Kalaczynski, P., Kang, W., Kappes, A., Kappesser, D., Karg, T., Karle, A., Katz, U., Kauer, M., Keivani, A., Kelley, J. L., Kheirandish, A., Kim, J., Kintscher, T., Kiryluk, J., Kittler, T., Klein, S. R., Koirala, R., Kolanoski, H., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Krings, K., Kroll, M., Krückl, G., Kunwar, S., Kurahashi, N., Kyriacou, A., Köpke, L., Labare, M., Lanfranchi, J. L., Larson, M. J., Lauber, F., Leonard, K., Leuermann, Martin, Liu, Q. R., Lohfink, E., Lozano Mariscal, C. J., Lu, L., Luszczak, W., Lünemann, J., Madsen, J., Maggi, G., Mahn, K. B. M., Makino, Y., Mancina, S., Mariş, I. C., Maruyama, R., Mase, K., Maunu, R., Meagher, K., Medici, M., Meier, M., Menne, T., Merino, G., Meures, T., Miarecki, S., Micallef, J., Momenté, G., Montaruli, T., Moore, R. W., Moulai, M., Nagai, R., Nahnhauer, R., Nakarmi, P., Naumann, U., Neer, G., Niederhausen, H., Nowicki, S. C., Nygren, D. R., O'Murchadha, A., O'Sullivan, E., Obertacke Pollmann, A., Olivas, A., Palczewski, T., Pandya, H., Pankova, D. V., Peiffer, P., Pepper, J. A., Pieloth, D., Pinat, E., Pizzuto, A., Plum, M., Price, P. B., Przybylski, G. T., Pérez de los Heros, C., Raab, C., Rameez, M., Rauch, L., Rawlins, K., Rea, I. C., Reimann, René, Relethford, B., Renzi, G., Resconi, E., Rhode, W., Richman, M., Robertson, S., Rongen, Martin, Rott, C., Ruhe, T., Ryckbosch, D., Rysewyk, D., Safa, I., Sanchez Herrera, S. E., Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Sarkar, S., Satalecka, K., Schaufel, Merlin, Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schumacher, Lisa Johanna, Schöneberg, S., Sclafani, S., Seckel, D., Seunarine, S., Soedingrekso, J., Soldin, D., Song, M., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stasik, A., Stein, R., Stettner, Jöran Benjamin, Steuer, A., Stezelberger, T., Stokstad, R. G., Strotjohann, N. L., Stuttard, T., Stößl, A., Sullivan, G. W., Sutherland, M., Taboada, I., Tenholt, F., Ter-Antonyan, S., Terliuk, A., Tilav, S., Toale, P. A., Tobin, M. N., Toscano, S., Tosi, D., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, Roxanne, Turley, C. F., Ty, B., Tönnis, C., Unger, E., Unland Elorrieta, M. A., Usner, M., Van Driessche, Ward, van Eijk, D., van Eijndhoven, N., van Santen, J., Vandenbroucke, J., Vanheule, S., Vraeghe, M., Walck, C., Wallace, A., Wallraff, Marius, Wandkowsky, N., Wandler, F. D., Watson, T. B., Weaver, C., Weiss, M. J., Wendt, C., Werthebach, J., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wiebe, K., Wiebusch, Christopher, Wille, L., Williams, D. R., Wills, L., Wolf, M., Wood, J., Wood, T. R., Woolsey, E., Woschnagg, K., Wrede, G., Xu, D. L., Xu, X. W., Xu, Y., Yanez, J. P., Yodh, G., Yoshida, S., Yuan, T. +329 morecore +5 more sourcesNuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome +5 morewiley +1 more sourceCutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna +12 morewiley +1 more sourceRemote Monitoring in Myasthenia Gravis: Exploring Symptom Variability
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background
Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer +13 morewiley +1 more source
