Results 111 to 120 of about 6,986,611 (336)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Psychometric Properties and Validity of a Brief Scale Measuring Basic Psychological Needs Satisfaction in Adolescents

open access: yesJournal of Educational, Cultural and Psychological Studies, 2019
Studies have shown that the satisfaction of basic psychological needs, as defined by Self-Determination Theory, has a great impact on adolescents’ well-being, prosocial behavior and academic success. In the present study, we aim to validate a brief scale
Laura Girelli   +5 more
doaj   +1 more source

NGO provision of basic education: alternative or complementary service delivery to support access to the excluded? [PDF]

open access: yes, 2007
While access to state schooling has grown in many countries in recent years, a hardcore of marginalised children continue to be excluded from this. Some of these children are able to gain access to education through non-state provision. The focus of this
Rose, Pauline M
core  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Web-based writing support: making it useable for distance teachers [PDF]

open access: yes, 2012
This paper considers the issues that distance teachers in higher education who are not writing specialists face in supporting their students’ academic writing development. We discuss the usefulness of open web-based writing support resources, and propose
Goodfellow, Robin   +2 more
core  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Precursors of September Arctic Sea-Ice Extent Based on Causal Effect Networks

open access: yesAtmosphere, 2018
Although standard statistical methods and climate models can simulate and predict sea-ice changes well, it is still very hard to distinguish some direct and robust factors associated with sea-ice changes from its internal variability and other noises ...
Sha Li   +8 more
doaj   +1 more source

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