Results 141 to 150 of about 6,986,611 (336)

MANAGEMENT OF THE EDUCATION SYSTEM

, 2023
The article deals with the methodological training of leaders in continuous education of the Republic of Uzbekistan, as well as the existing shortcomings in this area and ways to eliminate them through modern pedagogical theories, educational ...
openaire   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Broader Impacts for Ecologists: Biological Soil Crust as a Model System for Education. [PDF]

Front Microbiol, 2020
Faist AM, Antoninka AJ, Barger NN, Bowker MA, Chaudhary VB, Havrilla CA, Huber-Sannwald E, Reed SC, Weber B.   +8 more
europepmc   +1 more source

Women's Education in India: Trends, Interlinkages and Policy Issues [PDF]

Education is the basic requirement and the 'Fundamental Right' of the citizens of a nation. While Higher Education is important, the Elementary Education system serves as the base over which the Super-structure of the whole education system is built up ...
Mukherjee, Dipa
core   +1 more source

Development and construction of China [PDF]

, 2008
Libraries in China's higher education institutions have been developing in keeping pace with the flourishing development of China's higher education.
DAI Longji, Dai Longji (E-mail: dailj@lib.pku.edu.cn), SONG Jiao, SONG Xue, YAN Jinwei, ZHANG Yan, ZHENG Lan   +6 more
core  

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Theoretical Model of Curved Liquid Surface in the Microholes for Molding Microlenses

Optics
Microlenses are essential optics widely used in many fields. The microfluidics-assisted fabrication method provides a rapid, convenient way to manufacture microlenses. However, there is no mathematical model to describe the profile of the liquid surface.
Yuyang Shi, Yan Long, Xuhui Zhang, Li Wei, Bo Dai, Dawei Zhang   +5 more
doaj   +1 more source

Higher education in Japan : can the system change? : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Japanese Sociology at Massey University, Palmerston North, New Zealand [PDF]

, 1999
Some Japanese language throughoutThe topic for this thesis is: The Reform of Higher Education in Japan- Can the System Change? Since the establishment of the university system in the Meiji Restoration.
Burgiss, Angela
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source