Results 51 to 60 of about 869,560 (268)
Floral development in Paeonia suffruticosa ‘Doulv’ and functional characterization of the PsSEP1L
Scientia HorticulturaeTree peony (Paeonia section Moutan DC.) is of great ornamental value because of its diverse flower types; however, the molecular mechanisms governing its floral morphogenesis remain poorly understood.
Renjie Li +8 more
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Discrete Applied Mathematics, 2022 The study of structural graph width parameters like tree-width, clique-width and rank-width has been ongoing during the last five decades, and their algorithmic use has also been increasing [Cygan et al., 2015]. New width parameters continue to be defined, for example, MIM-width in 2012, twin-width in 2020, and mixed-thinness, a generalization of ...
Flavia Bonomo-Braberman +3 more
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Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Integrated regulatory network reveals the early salt tolerance mechanism of Populus euphratica
Scientific Reports, 2017 Salinization is one of the major factors that threaten the existence of plants worldwide. Populus euphratica has been deemed to be a promising candidate for stress response research because of its high capacity to tolerate extreme salt stress. We carried
Jiafei Chen +5 more
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2013 17 ...
Peter J. Humphries, Taoyang Wu
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Scientific Reports, 2020 Quantitative real-time PCR (qRT-PCR) is commonly used to measure gene expression to further explore gene function, while suitable reference genes must be stably expressed under different experimental conditions to obtain accurate and reproducible data ...
Kaikai Zhang +7 more
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