Results 91 to 100 of about 153,171,031 (220)
Advanced Science, Volume 13, Issue 62, 9 November 2026.Targeted protein degradation is often limited by the scarcity of usable E3 ligases. Herein, we report the first small‐molecule GPX4 degraders that incorporate either electrophilic warheads or a minimal azide group as an E3 recruitment ligand. The azide‐based degrader DK‐5070 effectively drives potent GPX4 degradation; mechanistic studies reveal that ...
Zehong Lin +14 more
wiley +1 more source
Transcriptome analysis and identification of genes related to environmental adaptation of Grylloprimevala jilina Zhou & Ren 2023. [PDF]
Ecol Evol, 2023 Zhou Y +7 more
europepmc +1 more source
, 2008 Biblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín, 5 - 3 planta; 28014 Madrid; Tel.
openaire +1 more source
RSF1‐Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites
Advanced Science, Volume 13, Issue 63, 12 November 2026.At sites of DNA damage, RSF1 recruits PARG to accelerate PAR turnover, triggering a switch from PAR‐driven condensates to 53BP1 condensates. This condensate transition enables p53‐dependent gene transcription and coordinates the DNA damage response.
Yungyeong Heo +10 more
wiley +1 more source
, 2015 Der Mehrwert des Einsatzes von historisch-fiktionalen Spielfilmen und Serien im Geschichtsunterricht wird von vielen GeschichtsdidaktikerInnen, HistorikerInnen und LehrerInnen seit Jahrzehnten diskutiert.
Harbauer, Verena
core +1 more source
Advanced Science, Volume 13, Issue 62, 9 November 2026.Chromosome 16q loss drives genomic instability through disruption of the CYLD–TIRR–53BP1 axis. CYLD preserves homologous recombination by stabilizing TIRR and limiting 53BP1 accumulation at DNA double‐strand breaks. CYLD deficiency redirects repair toward error‐prone non‐homologous end joining, promotes mutational burden and homologous recombination ...
Mingming Lu +14 more
wiley +1 more source
Population‐level diagnostic and radiation treatment trends of low‐risk prostate cancer
Cancer, Volume 132, Issue 21, 1 November 2026.Abstract Background Overtreatment of low‐risk prostate cancer (PC) undermines screening efforts. Active surveillance is preferred for low‐risk PC, but declining treatment may reflect diagnostic or treatment‐selection changes. We assessed diagnostic risk‐group trends among localized PC and low‐risk trends among radiation‐treated patients since 2010 ...
Steven M. Monda +18 more
wiley +1 more source
The conquests of Henry VIII: masculinity, sex and the national past in the Tudors’
, 2012 The Tudors (2007-2010) is a series that straddles the past and the present both in reconstructing events from a distant period in a modern accessible manner and in presenting itself generically as an old-fashioned ‘lavish epic’ with an ‘all-star cast ...
Glynn, B.
core +3 more sources
Molecular basis for histone H3 "K4me3-K9me3/2" methylation pattern readout by Spindlin1. [PDF]
J Biol Chem, 2020 Zhao F +9 more
europepmc +1 more source