Results 141 to 150 of about 131,565,998 (308)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The unified transform method for linear initial-boundary value problems: a spectral interpretation
, 2014 It is known that the unified transform method may be used to solve any well-posed initial-boundary value problem for a linear constant-coefficient evolution equation on the finite in-terval or the half-line. In contrast, classical methods such as Fourier
D. A. Smith
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Guide to the Records of the South Dakota Unified Judicial System
, 2016 Finding aid for the records of the South Dakota Unified Judicial ...
Finding aid prepared by Sara Casper, Government Records Archivist, and Miranda Webster, Processing Intern. +1 more
core
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Unified Newton’s method for matrix decompositions
Applicable Algebra in Engineering, Communication and ComputingAbstract We propose a way to unify the construction of Newton’s methods for matrix decompositions. This construction is based on a perturbation analysis of a suitable system associated with matrix decompositions.
openaire +2 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
VHDL-AMS: The Missing Link in System Design -
, 2008 After the IEEE ballot accepted the first draft language reference manual for VHDL-AMS (IEEE PAR 1076.1) in October 1997, we now can spend time and effort on applying the new arising methodology to real world problems outside the electronic domain.
Experiments With Unified
core
JasperNL/scip-unified: Code Repository for "A Unified Framework for Symmetry Handling"
A fork of a development version of SCIP v8.0.3 containing with code modifications for the unified framework for symmetry ...
fischer-gsc +29 more
core +1 more source