Results 51 to 60 of about 2,796,815 (256)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
The World and the New Frontiers of the U.S.
RSA Journal, 2011 This essay introduces the papers of the present monographic issue while dealing with the ongoing debate on the current role of the United States in the world.
Daniele Fiorentino
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Integrated pest management in the United States
California Agriculture, 1978 Integrated control has been used increasingly on many types of crops, nationwide. With the use of computers, scientists are coming to some surprising conclusions.
C Huffaker, B Croft
doaj
Undocumented Immigrants and Policy Advocacy: Reasserting the Activist Roots of Social Work
Columbia Social Work Review, 2014 The social work profession is positioned to play a critical role in redefining policies surrounding historically marginalized immigrants in the United States. The creation of the concept of the “undocumented immigrant” reflects an embedded discriminatory
Tatum Stewart
doaj +1 more source
Bats of the United States [PDF]
Public Health Reports (1896-1970), 1954 not possible to generalize with the singular and it is seldom possible with the plural. It can be truthfully stated that bats fly, but there ends the one characteristic that applies to all bats. Their manner of flight, habitat, migration, hibernation, breeding habits, and food preferences are as varied as similar activities among other mammals, for ...
openaire +2 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source