Results 91 to 100 of about 127,490,140 (248)

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

Unveiling the Revolutionaries: Cyberactivism and the Role of Women in the Arab Uprisings [PDF]

open access: yes, 2012
Courtney C. Radsch, a doctoral student at American University in Washington, D.C., explores how young women used social media and cyberactivism to help shape the "Arab Spring" and its ...
Radsch, Courtney C.
core  

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

Civil liberties in Tunisia following the 2011 uprisings

open access: yesRevista CIDOB d'Afers Internacionals, 2015
This article analyses the legislative changes made in relation to civil liberties in Tunisia since the 2011 revolts, specifically, those concerned with freedom of association, expression, and regulation of the media and links them to the socio-political ...
Carmelo Pérez Beltrán   +1 more
doaj  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim   +4 more
wiley   +1 more source

The Arab Uprisings and Their Fallout

open access: yes
Chapter 2 examines the Arab uprisings of 2010–2011, their background and varied paths and ramifications. Rather than separating these uprisings out as wholly distinctive, this chapter places them in the context of thirty years of struggle by the peoples ...
James L Gelvin
core   +1 more source

Lebanon and the Arab uprisings - [PDF]

open access: yes, 2014
Project. M.A.F.E. American University of Beirut. Department of Economics, 2014. Pj:1802First Reader : Dr. Simon Neaime, Professor, Economics ; Second Reader : Dr.
Khaled, Maher Assaad,
core  

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

Social Uprisings: Conceptualization, Measurement, Causes and Implications

open access: yes, 2015
The PhD thesis titled Social Uprisings: Conceptualization, Measurement, Causes and Implications consists of four stand alone papers. The first two papers are the essential building blocks to the overall thesis.
Shaheen, Sondos, Hayo, Bernd (Prof. Dr.)
core   +1 more source

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