Results 31 to 40 of about 1,218,553 (263)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Identity Politics and International Security of the Post-Soviet European States
RUDN Journal of Political Science, 2021 In the article, identity politics is understood as an intentional policy towards forcing and maintaining a macro-political identity. The authors also refer to the traditional understanding of identity politics as a political course focused on protecting ...
Lyubov A. Fadeeva, Dmitrij S. Plotnikov
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
The Militarization of State as a Factor of Geopolitical Competition
Проблемы постсоветского пространства, 2017 This article analyses the conception of collision between Russia and the West. It presents the history of U.S.-Soviet relations in the context of globalization. The authors note that, despite the end of the Cold War after breakup of the Soviet Union, the
A. V. Tolochko, I. A. Zaitseva
doaj
Büyük Güç Olma İddiasındaki Rusya’nın Afrika Politikası
Alternatif PolitikaI. Petro’dan miras kalan büyük güç olma ideali, Rus dış politikasının esasını oluşturmaktadır. Ülkede rejimler değişse de Rus yönetimlerinin büyük güç olma ideali hiç değişmemektedir.
Saffet Akkaya, Mustafa Üren
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Russia and the West: Contradictory Dialogue
Vestnik MGIMO-Universiteta, 2020 The authors focus on the historical evolution of the relations between Russia and the West and attempt to suggest their own vision on the future prospects. The aforementioned relationship span centuries of history. At times, these relations were peaceful,
T. V. Zonova, A. Giannotti
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Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source